清蛋白作为药物载体的PEG化修饰研究进展  

Research advances of PEGylation modification of albumin as drug carrier

作　　者：周琴琴[1,2] 陈建明[2] 

机构地区：[1]福建中医药大学药学院药物制剂教研室,福建福州350108 [2]第二军医大学药学院药剂学教研室,上海200433

出　　处：《药学实践杂志》2014年第4期241-245,265,共6页Journal of Pharmaceutical Practice

摘　　要：清蛋白(白蛋白)是一种理想的药物载体,但由于其在体内半衰期短以及易被酶降解等缺点限制了其应用,然而根据其具有多个修饰位点的结构特点,可通过PEG修饰延长循环时间,阻碍酶的作用等。目前,PEG修饰清蛋白仍处于研究阶段,已有较多关于PEG修饰清蛋白的研究,例如PEG修饰所起的作用、对清蛋白及其制剂的影响,以及修饰位点的选择等。本文对清蛋白的PEG化修饰的相关研究进行综述。Albumin is an ideal drug carrier,but its application was limited because of the shortcomings of short half-life and susceptible to enzymatic degradation in vivo.However,according to its structural features,albumin has a plurality of modification sites,which can be modified by PEG modifier to extend the cycle time and obstruct the action of the enzyme.Currently,the PEG-modified albumin is still in the research stage,and there have been many studies about PEG-modified albumin,such as the role of PEG modification,the effects on albumin and its preparations and the modification sites selection.The article reviewed the related studies about the PEGylation of albumin.

关 键 词：清蛋白 PEG化 半衰期 药剂学性质 修饰位点 

分 类 号：R945[医药卫生—微生物与生化药学]