异长春花苷内酰胺的光化学降解  

Photochemical Degradation of the Strictosamide

作　　者：刘文君[1,2] 李兆亮[2,3] 孟兆青[1,2,3] 孙林[2] 杨彪[2] 张珊[2] 程宁波[1,2] 丁岗[1,2] 王振中[2] 萧伟[1,2] 

机构地区：[1]江苏中康药物科技有限公司,南京210017 [2]江苏康缘药业股份有限公司,连云港222001 [3]中国药科大学药学院,南京210009

出　　处：《高等学校化学学报》2014年第8期1710-1714,共5页Chemical Journal of Chinese Universities

基　　金：国家'十二五'重大新药创制项目(批准号:2012ZX09102201-017)资助~~

摘　　要：报道了异长春花苷内酰胺在水溶液中经自然光照射后,发生光氧化反应,主要降解产物为(3S)-短小蛇根草苷.采用通入氧气和日光灯照射的方法可加速异长春花苷内酰胺光降解,(3S)-短小蛇根草苷的产率为56%.Photochemical reaction in the water solution of And the main degradation product, （3S） -pumiloside, was stictosamide was studied by HPLC and LC-MS. isolated and identified by 1H NMR, 13C NMR, HRMS and optical rotation. The fragmentation patterns of （3S）-pumiloside and other intermediates were ana- lysed by LC-MS. And then the mechanism of the strictosamide transformation into （3S）-pumiloside by light with O2 was also analysed. To improve the productivity of （3S）-pumiloside, the sunlight was replaced by light of fluorescent lamps. The productivity of （3S）-pumiloside was improved to 56% using light of fluorescent lamps and adding O2 into the stictosamide solution for accelerating degradation. This discovery shows a new green way to make the （3S）-pumiloside, and provided references for the structure transformation of similar compounds. This also gave the evidence that the strictosamide need to be stored against light.

关 键 词：异长春花苷内酰胺 (3S)-短小蛇根草苷 光化学降解 氧化 

分 类 号：O621.3[理学—有机化学]