托烷司琼预防腹腔镜胆囊切除术后恶心呕吐的临床效果  

Prophylactic effect of tropisetron on postoperative vomiting after laparoscopic cholecystecystectomy

作　　者：安玉洁[1] 代志刚[1] 于海[1] 李婷[1] 

机构地区：[1]石河子大学医学院,新疆石河子832000

出　　处：《中国实用医刊》2014年第16期28-29,共2页Chinese Journal of Practical Medicine

摘　　要：目的：观察托烷司琼预防腹腔镜胆囊切除术（ LC）术后恶心呕吐（ PONV）方案的临床疗效。方法选择在气管内插管全身麻醉下行LC的患者150例，随机分为五组：A组手术结束时（缝皮时）静脉注射0.9%生理盐水5 ml，B组麻醉诱导前10 min静脉注射托烷司琼2 mg，C组麻醉诱导前10 min静脉注射托烷司琼2 mg﹢地塞米松10 mg，D组麻醉诱导前10 min静脉注射托烷司琼5 mg，E组手术结束时（缝皮时）静脉注射托烷司琼2 mg。记录术后6、24 h内PONV程度。结果与A组相比，其余四组24 h内PONV的发生率明显下降，其中B、C、D、E组与A组比较差异有统计学意义（P﹤0.01或P﹤0.05），C、D组的发生率均低于B组（P﹤0.05）；C组与D组、B组与E组比较差异无统计学意义。结论托烷司琼2 mg联合地塞米松10 mg防治PONV效果较好，是一种经济、有效、安全且值得推广应用的止吐方法。Objective To observe the prophylactic effect of tropisetron on postoperative vomitting after laparoscopic cholecystectomy. Methods One hundred and fifty patients were divided into 5 groups randomly,respectively treated with saline 5 ml（ group A）,tropisetron 2 mg 10 minutes before anesthesia induction（ group B）,tropisetron 2 mg ﹢ dexamethasone 10 mg 10 minutes before anesthesia induction（ group C）,tropisetron 5 mg 10 minutes before anesthesia induction（ group D）,tropisetron 2 mg after LC（ group E）. Make a different record about the degree of PONV on patients 6 and 24 h after operation. Results The incidence of PONV on the other 4 groups decrease obviously within 24 h,comparing with group A;and the incidence of group C and D was lower than that in group B（ P﹤0. 05 ）. In addition,there was no significant difference between group C and D or between group B and E. Conclusions The prophylactic effect of tropisetron 2 mg﹢dexamethasone 10 mg on PONV is a kind of economic,effective,safe and application of popularization of anti-nausea method.

关 键 词：腹腔镜胆囊切除手术 术后恶心呕吐 托烷司琼 

分 类 号：R614[医药卫生—麻醉学]