CuBr_2催化的三组分反应合成喹啉-2,4-二羧基衍生物  

CuBr_2-Catalyzed Three-Component Coupling for Synthesis of Quinoline-2,4-dicarboxyl Derivatives

作　　者：王扣[1] 于浩飞[1] 丁林芬[1] 胡建林[1] 

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,昆明650500

出　　处：《有机化学》2014年第7期1437-1441,共5页Chinese Journal of Organic Chemistry

基　　金：云南省科技厅应用基础研究计划(No.2011FZ097)资助项目~~

摘　　要：以廉价的CuBr2为催化剂,发展了一种通过芳胺、乙醛酸酯与丙酮酸酯三组分反应制得喹啉-2,4-二羧基衍生物的简便有效方法.该方法具有很好的原子经济性,使用了便宜的催化剂和易得的试剂,在温和的条件下解决了以往喹啉-2,4-二羧基衍生物合成条件苛刻、产率低等问题,在生物活性分子和药物分子合成上有潜在的应用价值.A convenient and efficient method for synthesizing quinoline-2,4-dicarboxyl derivatives has been developed via a simple one-pot reaction of aromatic amines, glyoxylic ester, and pyruvate using low-costing CuBr2 as a catalyst. The method is atom efficiency, and utilizes non-expensive catalysts and easily available reagents, which provides an attractive approach to quinoline-2,4-dicarboxyl derivatives. This process has potential applications in the synthesis of biologically and medicinally relevant compounds.

关 键 词：喹啉-2 4-二羧基衍生物 芳胺 乙醛酸酯 丙酮酸酯 CuBr2 

分 类 号：O626[理学—有机化学] TQ460.1[理学—化学]