复方萆薢汤治疗尿酸性肾病临床观察  

Clinical Observation on Compound BiXie Tang in Treating Uric Acid Nephropathy

作　　者：苏筠霞[1] 徐筠[2] 苏建平[2] 李建华[1] 刘明龙[1] 

机构地区：[1]兰州大学第一医院肾病科,甘肃兰州730000 [2]兰州市第二人民医院

出　　处：《西部中医药》2014年第7期1-3,共3页Western Journal of Traditional Chinese Medicine

基　　金：兰州市科技局社会发展科技计划项目(编号2012-1-26)

摘　　要：目的:观察复方萆薢汤治疗尿酸性肾病的临床疗效。方法:将尿酸性肾病患者46例随机分为复方萆薢汤组(n=24)与别嘌呤醇组(n=22)。复方萆薢汤组予复方萆薢汤治疗,别嘌呤醇组予别嘌呤醇治疗,并于治疗前及治疗8周后检测2组患者血清尿酸(UA)、尿素氮(BUN)、肌酐(Cr)水平,于采血前24小时留取2组患者尿液检测24小时尿蛋白定量和尿肝脏型脂肪酸结合蛋白(L-FABP)定量。结果:复方萆薢汤组患者血清UA、BUN、Cr水平改善明显(P<0.05),效果优于别嘌呤醇组(P<0.05);复方萆薢汤组患者24小时尿蛋白定量和尿L-FABP明显减少,效果优于别嘌呤醇组,2组比较差异有统计学意义(P<0.05)。结论:复方萆薢汤能提高尿酸性肾病的临床疗效,并具有保护肾功能的作用。Objective： To investigate therapeutic effects of compoundBiXieTangin treating uric acid nephropathy（UAN）. Methods： All 46 patients were randomized into compoundBiXieTanggroup（n=24） and allopurinol group（n=22）. CompoundBiXieTanggroup took compoundBiXieTangand allopurinol group allopurinol, the levels of uric acid （UA） in the serum, blood urea nitrogen（BUN） and creatinine（Cr） of the patients in both groups were detected before treating and in eight weeks after treating, the urines of the patients were kept in 24 hours before drawing the blood, quantitative tests for 24 hours urine protein and liver fatty acid binding protein （L-FABP） in urine were performed. Results： The levels of UA, BUN and Cr of compoundBiXieTanggroup were improved notably（P〈0.05）, compoundBiXieTangwas superior to allopurinol（P〈0.05）; quantitative tests for 24 hours urine protein and L-FABP in urine of compoundBiXieTanggroup showed that they were lowered significantly, the decoction showed better effects compared with allopurinol, the difference had statistical meaning （P〈0.05）. Conclusion： CompoundBiXieTangcould raise therapeutic effects of treatment for UAN, and it could protect renal function.

关 键 词：肾病 尿酸性 UA BUN Cr L-FABP 复方萆薢汤 别嘌呤醇 

分 类 号：R259[医药卫生—中西医结合]