乳腺癌组织PTEN表达与血清Pleiotrophin水平的相关性研究  

Clinical significance of PTEN expression in tissue and pleiotrophin level in serum of breast cancer

作　　者：傅春玲[1] 徐金明[1] 张世琼[1] 刘定荣[1] 周琪[1] 李伟[1] 涂伟[1] 

机构地区：[1]重庆市涪陵中心医院病理科,重庆408000

出　　处：《海南医学》2014年第14期2168-2169,共2页Hainan Medical Journal

基　　金：重庆市卫生局医学科研计划研究项目(编号:2010-2-239);重庆市涪陵区科技计划项目(编号:2010ABB1069)

摘　　要：目的探讨乳腺癌组织中PTEN蛋白表达与血清多效生长因子(Pleiotrophin,PTN)水平的关系。方法采用免疫组化检测52例乳腺癌组织中PTEN蛋白表达,采用特异性酶联免疫吸附实验检测该组患者术前血清PTN水平。结果 PTEN阴性组36例,血清PTN平均值(566.34+464.51)pg/ml;PTEN阳性组16例,血清PTN平均值(408.68+170.77)pg/ml。两组比较血清PTN平均水平差异无统计学意义。结论乳腺癌的发生发展是一个复杂的过程,在乳腺癌的发生发展中PTEN和PTN或许是相互独立的因素,它们之间的关系还需要更多的证据来证明。Objective To investigate the expression of PTEN in breast cancer tissues and the level of pleiotrophin in breast cancer serums and study its relationship. Methods Using immunohistochemical to detect the expression of PTEN protein in breast cancer tissues of 52 cases, and using specific enzyme-linked immunosorbent experiment to test the level of PTN in preoperative serum of patients in this group. Results There were 36 patients in PTEN negative group with an average serum PTN value as （566.34＋464.51） pg/ml, while there were 16 cases in PTEN positive group with an average serum PTN value as （408.68＋170.77） pg/ml. There was no statistically significant difference in the average serum PTN values between the two groups. Conclusion The development of breast cancer is a complicated process. In the development of breast cancer, PTN and PTEN may be independent of each other, and the relationship between them still needs more evidence to prove.

关 键 词：乳腺癌 磷酸酶及张力蛋白同源物 多效生长因子 

分 类 号：R737.9[医药卫生—肿瘤]