合并房颤的急性脑梗死患者白介素-6、肿瘤坏死因子-α的水平及其与神经功能恢复关系  

Combined with atrial fibrillation in patients with acute cerebral infarction and interleukin-6, tumor necrosis factor alpha level and its relationship with nerve function recovery

作　　者：陆益就[1] 

机构地区：[1]广西玉林市第一人民医院神经内科,广西玉林537000

出　　处：《中国卫生产业》2014年第20期19-21,共3页China Health Industry

摘　　要：目的检测合并房颤的急性脑梗死患者血清白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)的水平,探讨IL-6、TNF-α与神经功能恢复的关系。方法应用ELISA法检测35例合并房颤急性脑梗死患者(房颤组)、52例单纯急性脑梗死患者(非房颤组)和35例门诊健康体检者(对照组)血清中IL-6、TNF-α水平。改良Rankin量表评定90d后房颤脑梗死组患者神经功能恢复情况。结果房颤组患者血清IL-6、TNF-α水平(16.74±5.45、25.50±4.37)较非房颤组(11.29±3.26、20.65±5.26)、对照组(5.27±0.45、12.34±3.67)明显升高,P均<0.01。预后良好房颤脑梗患者血清IL-6、TNF-α水平(14±3.79、20±2.33)较预后极差患者(18±4.73、29±2.65)明显低(P<0.01,P<0.05)。结论合并AF的脑梗死患者急性期血清IL-6、TNF-α水平明显升高,并且可作为判断AF脑梗死患者预后及转归的重要指标。Objective To explore the relationship between inflammatory factors and the recovery of neural function of atrial fibrillation in patients with acute cerebral infarction through detecting the serum interleukin-6（IL-6） and tumor necrosis factor-a（TNF-a）. Methods 35 cases merger of atrial fibrillation in patients with acute cerebral infarction,52 cases of non-atrial fibrillation in patients with acute cerebral infarction and 35 cases of health persons were selected.The serum IL-6 and TNF-a of all subjects were determined.And recovery was assessed by modified Rankin Scale （mRS） at 90 days follow-up in atrial fibrillation group.Results The levels of serum IL-6 and TNF-a in the atrial fibrillation group were significantly higher than in non-atrial fibrillation group, control group （all P〈0.01）. The levels of serum IL-6, TNF-a in the Good prognosis atrial fibrillation patients were significantly lower than the poor prognosis atrial fibrillation patients （P〈0.01,P〈0.05）.Conclusion The IL-6 and TNF-α of atrial fibrillation group obviously increased,and appears to be useful in prediction of stroke outcome for patients with atrial fibrillation.

关 键 词：急性脑梗死 心房颤动 白细胞介素6 肿瘤坏死因子A 

分 类 号：R542.22[医药卫生—心血管疾病]