蛋白质组学在肥胖和胰岛素抵抗及2型糖尿病中的应用研究进展  

Research Progress on the Application of Proteomics in Obesity,Insulin Resistance and Type 2 Diabetes

作　　者：王铭婕 闫朝丽[2] 

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特市010059 [2]内蒙古医科大学附属医院内分泌科

出　　处：《中国全科医学》2014年第21期2524-2527,共4页Chinese General Practice

基　　金：中华医学会临床医学科研专项基金资助(13040710456)

摘　　要：随着人民生活水平的提高,肥胖已经成为影响健康的重要因素。肥胖、胰岛素抵抗和2型糖尿病之间的关系密切,常被认为是疾病发展的连续阶段。蛋白质组学从整体蛋白质的水平,更深入、更接近生命本质的发现和探讨生命活动的规律以及疾病的发病机制,目前蛋白质组学的主要技术为双向电泳和质谱法,本文以目前研究技术为前提,着重介绍了蛋白质组学在肥胖、胰岛素抵抗、2型糖尿病及并发症方面的研究进展,通过检测一些相关的标志物,为研究2型糖尿病提供了新的视角。Withtheimprovementofpeople′slivingstandards,obesityhasbecominganimportantfactoraffecting health.The relationship between obesity , insulin resistance and type 2 diabetes is close , which is often considered as a continu-ous phase of disease development .On the base of the whole protein , proteomics can discover more deeper and more close life es-sence, and can explore the basic laws of life activities and mechanisms of disease , the major proteomic techniques consist of di-mensional electrophoresis and mass -spectrography.This article focuses on the progress of the current proteomic techniques , em-phatically introduces research progress on the application of proteomics in obesity , insulin resistance and type 2 diabetes, by de-tecting some relevant markers , providing a new insights into the study of type 2 diabetes.

关 键 词：蛋白质组学 肥胖 胰岛素抵抗 糖尿病 2型 Diabetesmellitus type2 

分 类 号：R587.1[医药卫生—内分泌]