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作 者:何茜冬[1] 唐妍[1] 张婷婷[2] 苏园园[2] 姚书忠[3] 郑妍[1]
机构地区:[1]中山大学附属中山市人民医院生殖中心,广东省中山市528403 [2]中山大学附属中山市人民医院妇产科,广东省中山市528403 [3]中山大学附属第一医院妇产科
出 处:《国际生殖健康/计划生育杂志》2014年第4期277-279,共3页Journal of International Reproductive Health/Family Planning
摘 要:目的:探讨宫腔内人工授精(IUI)在子宫内膜异位症(EMs)不孕患者腹腔镜术后半年的应用价值。方法:选择2010年1月-2012年12月在中山大学附属中山市人民医院不孕专科门诊就诊,经过常规系统检查后,行腹腔镜手术诊断为Ⅰ~Ⅲ期EMs并已进行手术治疗的不孕妇女98例,按患者意愿分为期待组42例、自然周期+宫腔内人工授精(NC+IUI)组38例、控制性促排卯+宫腔内人工授精(COS+IUI)组18例。比较术后半年的妊娠情况。结果:期待组周期妊娠率6.1%(12/197),半年累积妊娠率28.6%(12/42)。NC+IUI组周期妊娠率6.6%(4/61),半年累积妊娠率10.5%(4/38)。COS+IUI组周期妊娠率14.8%(4/27),半年累积妊娠率22.2%(4/18)。3组周期妊娠率和累积妊娠率比较,差异无统计学意义(P〉0.05)。结论:Ⅰ~Ⅲ期EMs不孕患者术后半年积极给予IUI的妊娠率与期待治疗相当,但此结论有待增加样本量进一步探讨。Objective: To investigate the clinical outcomes of intrauterine insemination (IUI) in infertility women with endometriosis in half year after laparoscopic treatment. Methods:Ninety-eight patients with endometriosis (stage Ⅰ -Ⅲ ) treated by laparoscopy, from January 2010 to December 2012 at Zhongshan People's Hospital, were divided into three groups: nature cycle plus IUI (NC +IUI), controlled ovarian hyperstimulation plus IUI (COS+IUI), and expectant treatment without IUI (ET control), with the informed consent. The pregnancy rates of three groups in half year after operation were compared. Results :The pregnancy rate per cycle, and the cumulative pregnancy rate in half a year were 6.1%(12/197) and 28.6%(12/42) in the ET control group, 6.6%(4/61) and 10.5%(4/38) in the NC+IUI group, and 14.8%(4/27) and 22.2%(4/18) in the COS+IUI group. Interestingly, there were no significant differences in those rates among three groups (P〉 0.05). Conclusions :There is not significant difference in the pregnancy rate in those infertility patients with endometriosis (stage Ⅰ-Ⅲ) in half year after the laparoseopic treatment combined with IUI and without IUI (expectant treatment). Of course, it is necessary to study further with more samples.
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