骨髓增生异常综合征难治性血细胞减少伴多系发育异常发病机制的进展  

Research Progress in the Pathogenesis Mechanism of Myelodysplastic Syndrome-Refractory Cytopenia with Multilineage Dysplasia

作　　者：姚永华[1] 叶成林[1] 浦权[1,2] 

机构地区：[1]上海市杨浦区市东医院血液科,上海200438 [2]上海市东医院浦权血液病骨髓病理诊断中心,上海200438

出　　处：《医学综述》2014年第14期2502-2504,共3页Medical Recapitulate

基　　金：上海市杨浦区卫生和计划生育委员会科研课题资助(201304)

摘　　要：根据世界卫生组织2008修订分类标准,难治性血细胞减少伴多系发育异常是骨髓增生异常综合征的最常见类型。随着认识的深入,发现其具有自身的发病特点,分类甚至可以进一步细化。该病的危险因素、流行病学、细胞遗传学、免疫与凋亡、骨髓微环境等发病特点也有较多新发现,可能有利于提供新的治疗思路。该文主要对其发病机制的研究进展进行综述。According to the criterion of WHO 2008,refractory cytopenia with muhilineage dysplasia （RCMD） is the most common type of myelodysplastic syndrome（MDS）.With the deeper insight of it,it has been found that RCMD has its own pathogenic characteristics,its classification can be even further elaborated.Many new discoveries of RCMD about risk factors,epidemiology,cytogenetics,immunology and apoptosis,bone marrow microenvironment have also been published,which can be used to provide new ideas to treat this disease.This article gives a review of the advances on pathogenesis of RCMD by summarizing the recent papers.

关 键 词：骨髓增生异常综合征 难治性血细胞减少伴多系发育异常 发病机制 

分 类 号：R551.3[医药卫生—血液循环系统疾病]