斑马鱼在鱼类病原免疫学研究中的应用  

Application of Zebrafish in the Fish Pathogen Immune Study

作　　者：吴唯维[1,2] 李盼[2,3] 柯翎[2] 李素一[2] 陈华[2] 陈叙[2] 林天龙[2] 林晨韬[2] 

机构地区：[1]福建师范大学生命科学学院,福建福州350108 [2]福建省农业科学院生物技术研究所,福建福州350003 [3]福建农林大学动物科学学院,福建福州350002

出　　处：《福建农业学报》2014年第6期602-607,共6页Fujian Journal of Agricultural Sciences

基　　金：福建省农业科学院引进海外人才项目(HWRC2011-02);国家自然科学基金项目(31300766)

摘　　要：斑马鱼全基因组测序已经完成,建立了多个专门的在线数据库,作为模式生物在遗传学、发育生物学等领域已得到了广泛的应用。本文介绍了斑马鱼用于鱼类病原免疫学研究的优点,包括个体发育过程透明、免疫系统较成熟,具有先天性和获得性2种免疫系统;多种鱼类来源的细菌和病毒在成年斑马鱼和胚胎中都能感染和复制,使其成为研究鱼类病原的入侵机制和宿主免疫应答的模式生物。同时,对当前已建立的鱼类细菌和病毒病原斑马鱼感染模型以及在疫苗方面的研究现状作简要概述。The zebrafish genome sequencing has been completed, and a number of specialized online databases have been established. As a model organism, zebrafish has been widely used in genetics, developmental biology and other fields. The advantages of zebrafish in fish etiology and immunology researches, such as transparent ontogenesis, mature immune system which contained both innate and adaptive immune system, and the supportive capacity for infection and replication of many fish-derived bacteria and viruses in the adults and the embryos~ have made it the most popular model organism for studying infectious pathogenesis and immune response of the fish. The established zebrafish infection models and their application on vaccinology of a variety of fish pathogenic bacteria and virus have been overviewed briefly in this report.

关 键 词：斑马鱼 病原 免疫 模式生物 

分 类 号：S942[农业科学—水产养殖]