人参多糖注射液联合树突状细胞干预非小细胞肺癌Th1/Th2的临床研究  

Clinical study on the intervention effect of Ginseng Polysaccharide Injection combined with DC on Th1/Th2 cells of NSCLC patients

作　　者：马俊杰[1,2] 徐彬[2] 刘会平[3] 周春祥[1,3] 

机构地区：[1]南京中医药大学基础医学院,南京210046 [2]江苏省沭阳县中医院肿瘤科,宿迁223600 [3]南京医科大学附属明基医院胸腔外科,南京210021

出　　处：《中华中医药杂志》2014年第8期2672-2675,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81273639)~~

摘　　要：目的:探索人参多糖注射液(GPS)联合树突状细胞(DC)对非小细胞肺癌(NSCLC)患者1型T细胞辅助细胞/2型T细胞辅助细胞(Th1/Th2)相关肿瘤免疫调节及无进展生存期(PFS)的影响。方法:60例NSCLC患者按照不同治疗方法随机分两组:对照组(DC治疗)、研究组(GPS联合DC治疗),每组各30例。两组肿瘤患者干预前后分别检测血清γ干扰素(INF-γ)、白细胞介素-4(IL-4)、白细胞介素-2(IL-2)、白细胞介素-5(IL-5);同时密切观察患者不良反应;最后通过随访统计患者PFS。结果:与治疗前比较,两组肿瘤患者治疗后,Th1(INF-γ、IL-2)及Th1/Th2(INF-γ/IL-4,IL-2/IL-5)升高,Th2(IL-4、IL-5)降低,差异有统计学意义(P<0.01);治疗后研究组Th1(INF-γ、IL-2)及Th1/Th2(INF-γ/IL-4,IL-2/IL-5)均高于对照组,差异有统计学意义(P<0.05),Th2(IL-4、IL-5)低于对照组,差异有统计学意义(P<0.05);两组患者出现少数皮疹及发热(低于38.5℃)不良反应,组间无差异,且皆可自行缓解;两组患者随访PFS:研究组>对照组(P<0.05)。结论:DC、GPS联合DC对NSCLC患者Th1/Th2及PFS皆具有不同程度作用;GPS对DC免疫调节及延长患者PFS具有协同作用,且较为安全。Objective： To explore the intervention effect of Ginseng Polysaccharide Injection （GPS） combined with DC on tumor immune modulation relevant to Thl/Th2 cells and progression-free survival （PFS） of NSCLC patients. Methods： 60 NSCLC patients were randomly divided into the control group treated by DC and the research group treated by GPS combined with DC, with 30 cases in each group. Before and after intervention, INF- γ, 1L-4, IL-2 and IL-5 were detected in serum from 2 groups of patients. Meanwhile, the adverse reactions were closely observed in the course of treatment. Finally, the PFS of NSCLC patients were found out by follow-up visit. Results： The Thl （INF- γ, IL-2） and Th1/Th2 （INF- γ/IL-4, IL-2/IL-5） in 2 groups of patients before treatment were higher than those in 2 groups of patients after treatment, while Th2 （IL-4, IL-5） before treatment were lower than those after treatment, with a statistical significance （P〈0.01）. After treatment, the Thl （INF- γ, IL-2） and the Th1/Th2 （INF-γ/IL-4, IL-2/IL-5） in the research group were higher than those in the control group, while the Th2 （IL-4, IL- 5） were lower, with a statistical significance （P〈0.05）. The adverse effects of rash and fever （less than 38.5℃） were noted in 2 groups of patients after treatment, without medications could relieve itself, with no intergroup difference. The PFS in the research group were longer than that in the control group （P〈0.05）. Conclusion： There are different levels of intervention effect of DC and GPS combined with DC on Th1/Th2 cells of NSCLC patients. GPS combined with DC has a synergistic effect in adjusting the immunity and prolonging PFS of NSCLC patients, and the combination therapy is relative safe.

关 键 词：人参多糖注射液 树突状细胞 非小细胞肺癌 1型T细胞辅助细胞 2型T细胞辅助细胞 无进展生存期 

分 类 号：R273[医药卫生—中西医结合]