散瘀和胃汤对胃癌前病变胃黏膜组织中let-7a的表达及临床症状的影响  

Effects of Sanyu Hewei Soup on symptom with the expression of let-7a and clinical symptoms

作　　者：席玉红[1,2] 汪伟[1,2] 孙晓娜[1,2] 张玉峰[1,2] 党中勤[1,2] 

机构地区：[1]河南省中医院 [2]河南中医学院第二附属医院肝胆脾胃病科,郑州450002

出　　处：《中华中医药杂志》2014年第8期2710-2712,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河南省科技攻关项目(No.122102310614);郑州金水区技术研究与开发经费支持项目(No.金科[2012]23号)~~

摘　　要：目的:观察散瘀和胃汤对胃癌前病变(PLGC)胃黏膜组织中let-7a的表达及对病理、临床症状的影响。方法:将76例PLGC患者随机分为两组各38例,治疗组脱落5例,对照组脱落7例。治疗组33例,对照组31例。治疗组给予散瘀和胃汤方治疗,对照组给予胃复春片治疗,治疗前后分别行电子胃镜检查并经内镜下活检。通过RT-PCR反应检测治疗前后let-7a的相对表达量,并观察两组临床症状和病理的改善情况。结果:治疗后,治疗组let-7a的相对表达量显著高于治疗前(P<0.01);对照组治疗前后let-7a的相对表达量差别不显著。治疗后,治疗组let-7a的表达水平显著高于对照组(P<0.01)。治疗后两组临床症状及病理积分均较治疗前显著降低(P<0.01);治疗组较对照组降低更显著(P<0.01)。结论:散瘀和胃汤治疗PLGC疗效显著,并能提高let-7a的表达量,有效改善临床症状。Objective： To observe the expression of let-7a and integral of pathology and clinic in precancerous lesions of stomach treated with Sanyu Hewei Soup. Methods： 76 patients were randomly divided into two groups, 38 cases in group. There are 5 patients and 7 patients loss from the treatment group and control group. The treatment group （33 cases） treated with Sanyu Hewei Soup and control group （31 cases） treated with Weifucun Tablets. Electronic gastroscopy and biopsy was used to detect the symptom and pathology. At the same time, the expression of the let-7a were analysised by RT-PCR. Results： There was a significant higher expression of let-Ta in treatment group （P〈0.01） and no significant difference was detected in control group before and after treatment. Compared with control group, there was a significant higher ratio of expression of the let-Ta in treatment group （P〈0.01）. There were a significant lower ratio of integral clinical symptoms and pathology in both group after treatment （P〈0.01）. Compared with control group, there was a significant lower ratio of integral in treatment group after treatment （P〈0.01）. Conclusion： Sanyu Hewei Soup may improve the expression of let-Ta in precancerous lesions and relieve clinical symptoms and display a significant treatment effect.

关 键 词：慢性萎缩性胃炎 胃癌前病变 微小RNA let-7a 

分 类 号：R273[医药卫生—中西医结合]