千金子石油醚部位化学成分的研究  

Study on Chemical Constituents of Petroleum Ether Extractant of Semen Euphorbiae

作　　者：朱娟娟[1] 张超[1] 王英姿[2] 孙秀梅[1] 

机构地区：[1]山东中医药大学 [2]北京中医药大学,北京100102

出　　处：《山东中医药大学学报》2014年第4期381-382,391,共3页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号:81274082);教育部高等学校博士学科点专项(编号:20110013120007);北京市自然科学基金项目(编号:7122093)

摘　　要：目的:对千金子石油醚萃取物进行化学成分研究。方法:采用硅胶柱色谱、凝胶柱色谱、制备薄层色谱等各种色谱技术对千金子的化学成分进行分离,通过理化数据分析和波谱分析方法鉴定化合物的结构。结果:从千金子石油醚萃取物中分离得到10个化合物,分别为3-O-苯甲酰基-5,15-O-二乙酰基续随子醇,3,7-O-二苯甲酰基-5,15-O-二乙酰基-7-羟基续随子醇,3-O-苯乙酰基-5,15-O-二乙酰基-6(17)-环氧续随子醇,千金二萜醇二乙酸烟酸酯,3-O-苯甲酰基-5,15,17-O-三乙酰基-17-羟基异续随子醇,胡萝卜苷,秦皮乙素,油酸甘油酯,水杨酸,油酸。结论:水杨酸为首次从该植物中分离得到。Objective：To study the chemical constituents of semen euphorbiae. Methods：The compounds were isolated by repeated chromatography of silica gel,Sephadex-20,Pre-TLC columns and their structures were identified on the basis of physicochemical properties and spectral analysis. Conclusions：Ten compounds were isolated,their structures were identified as 5,15-O-diacetyl-3-O-benzoyl-lathyol,5,15-O-diacetyl,3,7-O-dibenzoyl-7-hydroxylathyrol,5,15-O-diacetyl,3-O-phenyl-6（17）-epoxylathyrol,euphorbia factor L8,5,15,17-O-triacety-3-O-benzoyl-17 hydroxyisolathyrol,daucosterol,esculetin,glycerol-1-monooleate,salicylic acid,oleic acid. Conclusion：Salicylic acid is obtained from the plant for the first time.

关 键 词：千金子 石油醚萃取物 化学成分 结构鉴定 

分 类 号：R284.2[医药卫生—中药学]