乙肝病毒前S1抗原实验室检查结果分析  

Analysis of Pre-S1 antigen of hepatitis B virus in laboratory test results

作　　者：潘爱清[1] 李曦光[1] 左金华 王敏[1] 

机构地区：[1]蚌埠医学院第二附属医院检验科,安徽233000 [2]蚌埠中医院检验科,安徽233000

出　　处：《齐齐哈尔医学院学报》2014年第14期2053-2054,共2页Journal of Qiqihar Medical University

摘　　要：目的分析乙肝病毒前S1抗原检测结果及与HBV-DNA检测的关系。方法采用ELISA方法检测标本的HBsAg、HBsAb、HBcAb、HBeAg、HBeAb及乙肝病毒前S1抗原,同时采用PCR技术检测同一标本的HBV-DNA。结果在62例HBV感染者标本中前S1抗原阳性38例,HBV-DNA阳性43例,乙肝病毒前S1抗原在HBV-DNA阳性组的检出率显著高于HBV-DNA阴性组,两种检测结果有统计学意义(P<0.01)。结论血清乙肝病毒前S1抗原检测是HBV在体内复制的又一个可靠性指标。Objective To analyze hepatitis B virus pre-S1 antigen and its relationship with HBV-DNA detection. Methods HBsAg, HBsAb, HBcAb, HBeAg, HBeAb and Pre-S1 antigen of hepatitis B virus in Specimens were test by ELISA method, while the HBV-DNA was detected of the same specimen by PCR technology. Results The pre-S1 antigen positive of 38 cases in 62 cases of HBV infection specimens, the rate of Pre-S1 antigen of hepatitis B virus in HBV-DNA positive group was significantly higher than HBV-DNA negative group, there was statistically significant in two sets of test results （ P 〈 0. 01 ）. Conclusions The Pre-S1 antigen of hepatitis B virus in serum is a reliability index of HBV replication in vivo.

关 键 词：乙肝病毒前S1抗原 HBV-DNA 分析 

分 类 号：R446.62[医药卫生—诊断学]