肾结石患者红细胞膜ATP酶活性变化及相关性研究  

Changes of erythrocyte membrane ATPase activity and relativity research of nephrolith

作　　者：林满华[1] 王忠[2] 东野广智 

机构地区：[1]广东医学院医学检验系,广东湛江524023 [2]广东医学院附属医院泌尿外科,广东湛江524023

出　　处：《河北医学》2002年第5期387-389,共3页Hebei Medicine

摘　　要：目的 :探讨肾结石患者红细胞膜Ca2 + -Mg2 + -ATP酶 (Ca2 + -Mg2 + -ATPase)的活性变化与肾结石发生发展的相互关系。方法 :参照Shalev法检测 2 5名正常人和 30例肾结石患者红细胞膜Ca2 + -Mg2 + -ATPase活性 ;采用原子吸收火焰法测定红细胞内Ca2 + 和Mg2 + 浓度 ,并进行比较分析。结果 :肾结石患者红细胞膜Ca2 + -Mg2 + -ATPase活性明显增加 ,与正常对照组比较有显著性差异 (P <0 .0 1) ;而其红细胞内Ca2 + 含量明显下降 ,Mg2 + 含量则明显升高 (P均 <0 .0 1)。结论 :肾结石患者红细胞膜Ca2 + -Mg2 + -ATPase活性异常增加可能是导致或加速肾结石发生发展的原因之一。Objective: To discuss the changes of erythrocyte membrane ironic calcium and magnesium-ATPase activity in nephrolith, and the relativity which affects the occurrence and development of nephrolith. Methods: Adopting Shalev as described detecting erythrocyte membrane Ca 2+ -Mg 2+ -ATPase activity in 25 normal persons and 30 cases of nephrolith patients, erythrocyte Ca 2+ and Mg 2+ concentrations were detected by atomic absorption spectrophotometry and the results were compared. Results: Ca 2+ -Mg 2+ - ATPase activity significant increased in the nephrolith patients compared with that of control group with significant difference(P<0.01); Ca 2+ content in the erythrocyte decreased and Mg 2+ increased in nephrolith patients(P<0.01). Conclusion: The increase of Ca 2+ -Mg 2+ -ATPase activity in nephrolith patients could be one of factors to cause and accelerate nephrolith occurrence and development.

关 键 词：肾结石 红细胞膜 ATP酶 钙镁离子 

分 类 号：R692.4[医药卫生—泌尿科学]