Highly regio- and enantioselective synthesis of chiral polysubstituted 2H-pyrroles  

作　　者：XIE ZuoWei 

机构地区：[1]The Chinese University of Hong Kong

出　　处：《Science China Chemistry》2014年第8期1058-1058,共1页中国科学（化学英文版）

摘　　要：As one of the most important five-member heterocyclic aromatic rings, pyrrole is widely distributed in numerous natural products and pharmaceutical agents. Asymmetric dearomatization of pyrroles is very attractive in organic synthesis given the fact that highly functionalized chira pyrrolines and pyrrolidines could be easily accessed from the readily available pyrroles. However, the reported asymmetric dearomatization reactions of pyrroles are limited to transition-metal-catalyzed [4＋3] cycloaddition and hydrogenation reactions.As one of the most important five-member heterocyclic aromatic rings, pyrrole is widely distributed in numerous natural products and pharmaceutical agents. Asymmetric dearomatization of pyrroles is very attractive in organic synthesis given the fact that highly functionalized chira pyrrolines and pyrrolidines could be easily accessed from the readily available pyrroles. However, the reported asymmetric dearomatization reactions of pyrroles are limited to transition-metal-catalyzed [4+3] cycloaddition and hydrogenation reactions. The enantioselective intermolecular alkylative dearomatization of pyrroles is rare and challenging due to multiple selectivity issues including

关 键 词：对映选择性合成 区域选择性 吡咯 手性 过渡金属催化 加氢反应 环加成反应 五元杂环 

分 类 号：O626.13[理学—有机化学]