RNA解旋酶和应激颗粒  

RNA Helicases and Stress Granules

作　　者：徐峰[1] 夏君[1] 张萍[1] 

机构地区：[1]中山大学中山医学院免疫学教研室,热带病防治研究教育部重点实验室,广州510080

出　　处：《中国生物化学与分子生物学报》2014年第7期630-635,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.81171576;No.81371794);广东自然科学基金(No.S2013010016454)资助项目~~

摘　　要：应激颗粒(stress granules,SGs)是细胞在环境压力刺激下停止蛋白质翻译后,mRNA与多种细胞蛋白组装而成的胞质颗粒结构.RNA解旋酶家族作为生物体内普遍存在的一类高度保守的蛋白质酶类,参与了RNA代谢各个环节,近年来其家族成员被陆续发现是一类新的SG重要组分.本文综述了RNA解旋酶参与应激颗粒形成过程,RNA解旋酶家族蛋白的结构和其参与应激颗粒形成的研究进展.Cells silence ongoing protein synthesis in response to different environmental stresses, and thestalled mRNA and cellular proteins transiently form cytoplasmic aggregates termed as stress granules（SGs）. The components of SGs vary in response to different stresses. As a group of ubiquitously-expressed and highly-conserved enzymes, RNA helicase family is actively invovled in nearly all processesof RNA metabolism. Recently, a growing number of RNA helicases have been identified to be novelcomponents of stress granules. This review summarizes recent progresses on formation of SGs, structuresof RNA helicases and involvements of RNA helicases in SG formation.

关 键 词：应激颗粒 RNA解旋酶 压力 

分 类 号：R392.12[医药卫生—免疫学]