2型糖尿病患者尿酸结石形成的相关因素分析  

Analysis of related factors in forming uric acid stones in patients with type 2 diabetes

作　　者：谢礼仁 金岩[1] 田明丽[1] 曹石金[1] 曾灿[1] 

机构地区：[1]深圳市坪山新区人民医院泌尿外科,广东深圳518118

出　　处：《中国医药科学》2014年第13期28-30,共3页China Medicine And Pharmacy

基　　金：广东省深圳市坪山新区医疗卫生发展孵化资助资金项目(201208)

摘　　要：目的探讨2型糖尿病(T2DM)患者尿酸结石形成的相关因素及机制。方法选择T2DM合并尿酸结石患者50例纳入观察组,随机选取同期诊治的未合并尿酸结石的T2DM患者50例纳入对照组,比较两组患者临床资料及生化指标的差异。结果观察组与对照组患者在年龄、性别、SBP、DBP、TC、FBG、2hPBG、HbA1C比较差异无统计学意义(P>0.05),而两组患者在BMI、尿pH值、HOMA-IR、SUA、TUA方面比较差异有统计学意义(P<0.05),多因素Logistic回归分析显示尿pH值、HOMA-IR是2型糖尿病患者尿酸结石形成的独立危险因素(P<0.05)。结论高尿酸血症、高尿酸排泄、胰岛素抵抗、超重或肥胖、高甘油三酯血症在2型糖尿病患者尿酸结石形成中具有重要作用,其中尿pH值、HOMA-IR是2型糖尿病患者尿酸结石形成的独立危险因素。ObjectiveTo investigate the factors and mechanisms in forming uric acid stones in patients with type 2 diabetes（T2DM）.Methods 50 T2DM patients with uric acid stones were included into the observation group, and 50 T2DM patients without uric acid stones were randomly selected as the control group,the clinical and biochemical indicators were compared in the two groups.ResultsThere were no significant difference in observation group and control group in age,sex,SBP,DBP,TC,FBG,2hPBG and HbAlC（P〉0.05）,and there were of statistical difference significance in BMI,urinary pH,HOMA-IR,SUA,TUA in the two gruop（P〈0.05）,and theLogistic regression analysis showed the urinary pH,HOMA-IR,SUA were independent risk factors in uric acid stone formation in T2DM（P〈0.05）. Conclusion Hyperuricemia and high uric acid excretion,insulin resistance, overweight or obese, hypertriglyceridemia is play an important role in type 2 diabetes in uric acid stone formation,and the urinary pH,HOMA-IR,SUA were independent risk factors in uric acid stone formation in T2DM.

关 键 词：糖尿病 尿酸结石 胰岛素抵抗 高尿酸血症 

分 类 号：R587[医药卫生—内分泌]