血清高密度脂蛋白胆固醇水平用于评价肝脏合成功能的价值  

Value of serum high-density lipoprotein cholesterol levels in evaluating liver function

作　　者：黄文彩[1] 陈璇[1] 余洁玲[1] 方爱娟[1] 尹丽明[1] 李金洳 

机构地区：[1]广东医学院附属东莞市厚街医院检验科,广东东莞523945

出　　处：《中国医药科学》2014年第13期118-119,142,共3页China Medicine And Pharmacy

摘　　要：目的探讨血清高密度脂蛋白胆固醇(HDL-C)水平用于评价肝脏合成功能的价值。方法选择我院收治的肝病患者及体检正常者作为研究对象并进行分组,应用全自动生化分析仪对研究对象的血清HDL-C水平进行测定,并进行组间结果比较。结果对照组HDL-C水平为(1.28±0.20)mmol/L,肝病组为(0.77±0.15)mmol/L,其中肝炎组为(0.81±0.13)mmol/L,肝硬化组为(0.68±0.14)mmol/L,肝癌组为(0.54±0.05)mmol/L。肝病组以及肝病组内肝炎、肝硬化、肝癌患者的血清HDL-C水平均显著低于对照组(P<0.05);肝病组内肝硬化、肝癌患者的血清HDL-C平均值均显著低于肝炎患者(P<0.05);肝癌患者血清HDL-C平均值显著低于肝硬化患者(P<0.05)。结论血清HDL-C的具体水平可以反映肝病患者的肝脏合成功能,其数据水平越低,表示损伤越严重,查明其具体水平,对于及时进行治疗具有极大的参考价值。ObjectiveTo study value of serum high-density lipoprotein cholesterol（HDL-C） levels in evaluating liver function. Methods Liver disease patients and normal physical examinationer in our hospital were slected as the research objects and grouped. Automatic biochemical analyzer was applied to determine serum HDL-C level of research object, and results between groups were compared.Results HDL-C level of control group was （1.28±0.20） mmol/L. Liver disease group was （0.77±0.77） mmol/L. Hepatitis group was （0.81±0.13） mmol/L. Liver cirrhosis group was （0.68±0.14） mmol/L, and （0.54±0.05） mmol/L for liver cancer group. Patients’ serum HDL-C levels in hepatitis group, liver cirrhosis group, liver cancer group were significantly lower than that of control group （P〈0.05）; Serum average HDL-C levels of patients in liver cirrhosis group, liver cancer group were significantly lower than patients in hepatitis group（P〈0.05）; Average serum HDL-C levels of patients in liver cancer were significantly lower than that of patients with cirrhosis （P〈0.05）.Conclusion Specific level of serum HDL-C can reflect hepatic synthetic function in patients with liver disease. The lower its level is, the more serious the damage is. Finding out the specific level is of great reference value for the timely treatment.

关 键 词：肝炎 肝硬化 肝肿瘤 高密度脂蛋白胆固醇 

分 类 号：R446.1[医药卫生—诊断学]