多菌型麻风患者联合化疗6个月后停药随访7年结果分析  

Analysis on Results of Seven Year Following up among Multibacillary Patients Treated with Multidrug Therapy for Six Months

作　　者：沈建平[1] 严良斌[1] 余美文[1] 李进岚[2] 余秀峰 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,江苏南京210042 [2]贵州省疾病预防控制中心,贵州贵阳550004 [3]文山州皮肤病防治研究所,云南文山663000

出　　处：《皮肤性病诊疗学杂志》2014年第3期181-184,共4页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：世界卫生组织项目(编号:L42/181/192)

摘　　要：目的:分析多菌型麻风患者经过6个月联合化疗后停药,随访7年的结果。方法:对新发或复发未经治疗的多菌型麻风患者给予WHO联合化疗多菌型方案治疗6个月,停药后观察7年,评价临床和细菌学疗效。结果:共收录多菌型麻风患者114例,中途退出43例,71例纳入分析。疗前患者平均细菌指数为2.93±1.39,停药满7年时所有患者细菌指数阴转,平均年下降0.42。7年中共观察到麻风反应38人次,反应频率为53.5%。有1例在停药13个月时复发,复发率为0.05/100人年。结论:多菌型麻风患者6个月联合化疗有效。联合化疗6个月患者的细菌指数变化和麻风反应与报告的经1年或2年联合化疗的多菌型患者情况相似。To analyze the results of treatment among MB patients 7 years after trea-ted with six months’ multidrug therapy.Methods：Newly detected and relapsed MB leprosy pa-tients were treated with 6 months’ WHO multidrug therapy.Then the patients were followed up for 7 years.The effectiveness of treatment was analyzed by clinical status and bacteriological studies. Results：A total of 114 patients were recruited.43 patients were withdrawn from the study.Only 71 patients were qualified for analysis.The mean bacteriological index （ BI ） of all patients de-creased from 2.93 ±1.39 before treatment to 0 at the end of seventh year’ following up with annu-al BI decrease of 0.42 .The rate of smear negativity of all patients was 100%at the end of seven year’ following up.There were 38 leprosy reactions observed during the study with a rate of 53.5%and one patient relapsed with a relapse rate of 0.05 per 100 patient year.Conclusion：Multidrug therapy for 6 months was effective in MB patients, the frequencies for decreased BI and leprosy reactions were similar to those accepted the therapy for 1 or 2 years.

关 键 词：麻风 联合化疗 细菌指数 麻风反应 

分 类 号：R755[医药卫生—皮肤病学与性病学]