微生物源农药申嗪霉素的研制与应用  

Progress on the development and application of biopesticide Shenqinmycin

作　　者：方运玲 孙爽[1] 申阅[1] 何亚文[1] 

机构地区：[1]上海交通大学 生命科学技术学院微生物代谢国家重点实验室,上海200240

出　　处：《农药学学报》2014年第4期387-393,共7页Chinese Journal of Pesticide Science

摘　　要：申嗪霉素是中国自主研发的一种新型微生物源农药,具有高效、安全、广谱等特点,其主要成分是甜瓜根际促生菌M18产生的次级代谢产物吩嗪-1-羧酸。文章重点就申嗪霉素产生菌M18的分离及其代谢产物的鉴定、申嗪霉素生物合成及调控机理最新研究进展、申嗪霉素高产工程菌株的构建和产业化、以及申嗪霉素大田防病试验结果及推广应用情况等进行详细综述,并对其抗菌作用机理进行探讨,旨在为申嗪霉素的生物合成机理研究、遗传和代谢改造以及推广应用提供参考。Shenqinmycin is a newly developed biopesticide containing the secondary metabolite phenazine-1-carboxylic acid （ PCA ） produced by Pseudomonas sp. M18. The discovery and characterization of Pseudomonas sp. M18 as well as the identification of metabolites were firstly introduced;The progress on Shenqinmycin biosynthetic mechanism and regulatory network was then summarized; The construction of high-yield engineered strain and industrialization of Shenqinmycin were further introduced;Finally, the application of Shenqinmycin in plant disease control and possible antifungal mechanisms of shenqinmycin were discussed.

关 键 词：假单胞菌M18 微生物源农药 申嗪霉素 吩嗪-1-羧酸 

分 类 号：S482.292[农业科学—农药学]