肝康Ⅱ号对重型肝炎内毒素血症的影响  

Effect of Gankang Ⅱ on endotoxemia in patients with severe hepatitis

作　　者：李金科[1] 李云静[1] 谢杏榕[1] 胡波[1] 杜卫星[1] 谭华炳[1] 

机构地区：[1]湖北医药学院附属人民医院感染性疾病科,湖北十堰442000

出　　处：《中国肝脏病杂志（电子版）》2014年第2期53-55,共3页Chinese Journal of Liver Diseases：Electronic Version

摘　　要：目的观察肝康Ⅱ号对重型肝炎内毒素血症的影响,探讨其作用机理,为临床用药提供依据。方法随机选择本院收治的重型肝炎患者40例分为治疗组(20例)和对照组(20例)。对照组给予重型肝炎的护肝、退黄等综合治疗,治疗组在常规给予重型肝炎的护肝、退黄等综合治疗的基础上,加用肝康Ⅱ号治疗,每日1剂,分两次服,疗程2周。治疗前后分别检测两组患者血清TBil、ALB、PTA、血清内毒素(endotoxin,ET)、血清肿瘤坏死因子α(TNF-α)水平。结果治疗后两组TNF-α、ET、ALT、TBil水平显著下降(P均<0.01),ALB、PTA水平显著升高(P均<0.05);治疗组各项指标均优于对照组,两组患者TNF-α、ET、TBil、ALB、PTA水平差异均有显著统计学意义(P均<0.01)。对照和治疗组好转率分别为40%和60%,两组差异无统计学意义(P>0.05)。结论肝康Ⅱ号可以明显改善患者肝功能、血清内毒素水平,提高重型肝炎的治疗效果,其治疗机理可能与抑制内毒素的产生与释放和促进内毒素排出有关。Objective To investigate the effects of GankangⅡon the hepatitis endotoxemia and explore its mechanism of action, provide the basis for clinical use. Methods Total of 40 patients with severe hepatitis were divided into treatment group （20 cases） and control group （20 cases）. The basis of the control group received liver protective, jaundice-relidf and other comprehensive treatment, the treatment group received conventional liver protectve in severe hepatitis, jaundice-relief and other comprehensive treatment, the addition of Gankang No.Ⅱday one, bid, for 2 weeks. Both groups before and after treatment were detected in serum of patients TBil, ALB, prothrombin activity （PTA）, serum endotoxin （endotoxin, ET）, tumor necrosis factor α（TNF-α） levels. Results The TNF-α, ET, ALT, TBil levels decreased significantly after treatment （all P 0.05）. Conclusions Gankang Ⅱ can significantly improve liver function, serum endotoxin levels, improve the treatment of severe hepatitis. Its therapeutic mechanism may be related to the inhibition of the production and release of toxins and the promotion of related toxins.

关 键 词：肝康Ⅱ号 重型肝炎 内毒素血症 中医药治疗 

分 类 号：R259[医药卫生—中西医结合]