不同病毒感染后宿主细胞免疫功能的变化与分析  

The differences of host's cellular immunity after different virus infection.

作　　者：田瑛[1] 任东伟[1] 张娟[1] 王红[1] 

机构地区：[1]首都医科大学附属北京友谊医院感染暨急救医学科,北京100050

出　　处：《临床和实验医学杂志》2014年第16期1379-1382,共4页Journal of Clinical and Experimental Medicine

基　　金：北京市中医青年科学研究资助项目(QN2009)

摘　　要：目的通过检测不同病毒感染急性期患者外周血淋巴细胞亚群，比较其差异，了解不同病毒感染对宿主细胞免疫功能的影响并分析其临床意义。方法收集2010～2013年感染科门诊及住院收治的51例病毒感染急性期患者及20例正常对照，检测其外周血淋巴细胞亚群，比较其差异并分析临床意义。结果与正常对照相比，病毒感染患者外周血NK细胞、B细胞比率减少，T细胞比率升高；T细胞亚群中CD4＋CD28＋T细胞和CD8＋CD28＋T细胞比率降低，CD8＋T细胞以及CD8＋CD38＋T细胞比率升高。EB病毒感染后T细胞、CD8＋T细胞、CD8＋CD38＋T细胞比率升高较其他病毒感染更为显著。结论病毒感染患者存在免疫功能紊乱，天然免疫、体液免疫及细胞免疫功能下降同时伴有细胞免疫异常激活，EB病毒感染较其他病毒免疫激活更为明显。Objective To investigate the different changes of hostg cellular immunity in patients with different virus infection by compa- ring peripheral blood lymphocyte subsets. Methods Flow cytometry was used to detect the peripheral blood lymphocyte subsets among 51 patients infected with Epstein - Barr virus, cytomegalovirus or other virus. Results In contrast to the normal controls, percentage of T ceils increased, and percentage of B/NK cells decreased among the patients with acute virus infection. Meanwhile, within T cell subsets, percentage of CD8 ＋ T cells and CD8 ＋ CD38＋ T ceils increased ; and percentage of CD4 ＋ CD28 ＋ T ceils and CD8 ＋ CD28 ＋T ceils decreased. And percentage of T ceils, CD8 ＋ T cells and CD8＋ CD38 ＋ T cells was higher among the patients infected with Epstein - Barr virus than that among the patients infected with cytomegalovirus or other virus. Conclusion There was immune turbulence among patients with virus infection. Natural immunity, humoral immu- nity and cellular immunity all decreased while cellular immunity activated abnormally. The immune activation of the patients infected with Epstein - Barr virus was more obvious than that of patients infected with other virus.

关 键 词：病毒感染 细胞免疫 淋巴细胞亚群 

分 类 号：R392[医药卫生—免疫学]