咳嗽变异性哮喘患儿血清过敏原检测与血中嗜酸性粒细胞、免疫球蛋白的关系  

Relationship between serum allergen detection in children with cough variant asthma and blood eosinophils and immunoglobulin

作　　者：可秋萍[1] 张永梅[1] 张建华[1] 娄莹[1] 王桂芳[1] 殷玲[1] 尚莹[1] 

机构地区：[1]河南省新乡市中心医院儿科,453000

出　　处：《中国妇幼保健》2014年第23期3764-3766,共3页Maternal and Child Health Care of China

基　　金：河南省新乡市科技进步贰等奖〔2013-J-2053-R01/12〕

摘　　要：目的:探讨咳嗽变异性哮喘患儿(CVA)血清特异性免疫球蛋白E(SIgE)与血清总免疫球蛋白E(TIgE)、血嗜酸性粒细胞(EOS)百分比的关系,了解血清TIgE、血EOS百分比增高水平是否与SIgE抗体反应级别有关。方法:对50例CVA患儿及正常体检的21例儿童测定TIgE、外周血EOS和SIgE抗体,根据血清SIgE抗体反应级别分为强阳性组、弱阳性组,正常的21例儿童作为对照组,3组分别与TIgE、血EOS百分比对照研究。结果:强阳性组TIgE、血EOS百分比明显增高,与弱阳性组、对照组对比,有统计学差异(P<0.05),而弱阳性组与对照组的TIgE、血EOS百分比对比,无统计学差异(P>0.05)。结论:CVA患儿TIgE、血EOS百分比增高与SIgE抗体反应呈强阳性者有明显关系,而与SIgE反应呈弱阳性者无明显关系,提示SIgE检测对儿童CVA的临床诊断治疗和疾病预防所提供的信息比TIgE、血EOS百分比更准确。Objective： To explore the relationship between serum specific immunoglobufin E （slgE） and serum total immunoglobulin E （tIgE） , the proportion of blood eosinophils （EOS） in children with cough variant asthma （CVA） , understand whether increasing amplitude of serum tIgE and proportion of blood EOS are correlated with grade of sIgE antibody response. Methods ： tIgE, blood EOS in peripheral blood and sIgE antibody were detected in 50 CVA children and 21 normal children after physical examination （control group） ; the CVA children were divided into strong positive group and weak positive group according to the grade of sIgE antibody response; tIgE levels and blood EOS proportions in the three groups were compared and researched. Results： tIgE level and blood EOS proportion in strong positive group increased significantly, compared with weak positive group and control group, there were statistically significant differences （P 〈 0. 05）, but there was no statistically significant difference in tlgE level and blood EOS proportion between weak positive group and control group （P 〉 0.05 ） . Conclusion： The increases of tIgE level and blood EOS proportion in CVA children are significantly correlated with strong positive sIgE antibody reaction, but they are not correlated with weak positive sIgE antibody reaction, which indicates that slgE detec- tion can provide more accurate information for clinical diagnosis, treatment and prevention of CVA children compared with tIgE and blood EOS proportion.

关 键 词：咳嗽变异性哮喘 血清过敏原 嗜酸性粒细胞 免疫球蛋白 

分 类 号：R725.6[医药卫生—儿科]