系统性红斑狼疮患者特异性抗体与病毒感染的相关性分析  

Correlation analysis of specific antibodies and viral infections in patients with systemic lupus erythematosus

作　　者：黄丽云[1] 符火[1] 高飞[1] 

机构地区：[1]海南医学院附属医院检验科,海南海口570102

出　　处：《中华医院感染学杂志》2014年第15期3682-3683,3686,共3页Chinese Journal of Nosocomiology

基　　金：海南省自然科学基金资助项目(30020)

摘　　要：目的通过检测系统性红斑狼疮(SLE)患者外周血中抗中性粒细胞胞浆抗体(ANCA)与抗心磷脂抗体(ACA),分析其与病毒感染的相关性,探讨病毒可能的作用机制。方法选取2008-2012年医院就诊的100例SLE患者设为SLE患者组,选取同期医院体检的80名健康人员设为对照组,检测两组人群外周血中自身抗体ANCA、ACA,以及外周血中EB病毒(EBV)、巨细胞病毒(CMV)、丙型肝炎病毒(HCV)的特异性抗体,分析3种病毒感染与自身抗体相关性。结果 SLE患者组ANCA与ACA的阳性率分别为21.00%、33.00%,对照组为3.75%、5.00%,SLE组自身抗体阳性率显著高于对照组,两组比较差异有统计学意义(P<0.05);ANCA阳性人群中,SLE患者组抗EBV-VCA-IgA抗体阳性率61.90%,对照组为0,组间比较差异有统计学意义(P<0.05);ACA阳性人群中两组抗EBV-VCA-IgA、抗CMV-IgM及抗HCV抗体阳性率差异均无统计学意义。结论 EBV感染对SLE患者自身抗体ANCA的产生具有一定的影响,未发现CMV及HCV感染对SLE患者自身抗体的影响。OBJECTIVE To detect antineutrophil cytoplasmic antibody （ANCA） and anticardiolipin antibody （ACA） in peripheral blood of patients with systemic lupus erythematosus （SLE）, analyze the correlation of these antibodies and viral infections and explore the possible mechanisms of virus. METHODS Totally 100 SLE patients admitted in our hospital from 2008 to 2012 were set as the SLE group, 80 healthy persons by physical examina- tions during the same period were selected as the control group. The autoantibodies ANCA and ACA as well as the specific antibodies of EB virus （EBV）, cytomegalovirus （CMV）, hepatitis C virus （HCV） in peripheral blood were detected, the correlation of the above three kinds of viral infections and autoantibodies was analyzed. RESULTS The positive rates of ACA and ANCA were 21.00% and 33. 00% in the SLE group, and were 3.75%, and 5.00 % in the control group, indicating that the positive rate of autoantibodies in the SLE group was significantly higher than thou in the control group, the difference was significant （P〈0.05）. In the ANCA-positive population, the positive rate of anti-EBV-VCA-IgA antibody was 61.90% in the SLE group and was 0 in the control group, with significant difference between the groups （P〈0.05）. There was no significant difference in the positive rate of anti-CMV-IgM, anti-HCV antibodies between the two groups in the ACA-positive population. CONCLUSION The study results, suggest that EBV infection has a certain influence on ANCA autoantibody production in SLE patients, while it is still not found that CMV and HCV infections have influences on autoantibodies in patients with SLE.

关 键 词：系统性红斑狼疮 自身抗体 病毒感染 

分 类 号：R373[医药卫生—病原生物学]