巨细胞病毒抗体对高血压患者血清内皮素与P-选择素的影响  

Effect of CMV-Ab on plasma endothelin and P-selectin in patients with hypertension

作　　者：祝炜[1] 郑琼莉[1] 周军[1] 田立群[1] 徐全胜[1] 

机构地区：[1]武汉市第一医院心血管内科,湖北武汉430022

出　　处：《中华医院感染学杂志》2014年第15期3684-3686,共3页Chinese Journal of Nosocomiology

基　　金：湖北省卫生厅科研基金资助项目(鄂卫[2012]84-2012Z-Y12)

摘　　要：目的探讨高血压病患者人类巨细胞病毒(HCMV)抗体对血清内皮素、P-选择素及并发症的影响,为临床资料提供参考依据。方法回顾性分析2012年4月-2013年5月在医院治疗的68例高血压病患者临床资料,并选择同期来医院体检的健康人群66名作为对照组进行比较观察,数据采用SPSS16.0软件进行分析。结果高血压组IgM阳性率为55.88%、IgA阳性率为89.71%、IgM+IgA阳性率54.41%;对照组分别为19.70%、74.24%、16.67%;高血压组患者HCMV抗体IgM、IgA阳性及二者双阳性率明显高于健康对照组(P<0.05);高血压组IgM阳性患者血浆内皮素、P-选择素水平分别为(95.47±5.12)pg/ml、42.54±3.29,IgM阴性患者分别为(70.83±4.61)pg/ml、27.47±5.61,对照组分别为(46.93±6.00)pg/ml、19.59±4.31;高血压明显高于对照组(P<0.05)。结论病毒感染后可显著提高高血压患者血浆内皮素、P-选择素水平,增加并发症的发生。OBJECTIVE To investigate effect of human cytomegalovirus antibodies （HCMV-Ab） on serum endothelin, P-selectin and complications in hypertensive patients. METHODS A retrospective analysis on clinical data of 68 patients with essential hypertension in our hospital from Apr. 2012 to May 2013 was conducted, and 66 healthy people in the medical examination center of our hospital during the same period were chosen as a control group for comparative observation. Data were analyzed with SPSS 16.0. RESULTS The positive rate of IgM and IgA was 55.88%, 89.71% in the hypertensive group, and 19.70%, 74.24% in the control group, the rate of patients whose IgM and IgA were both positive was 54.41% in the hypertensive group, and 16.67% in the control group. The HCMV-Ab IgM, IgA-positive rate and the double-positive rate was significantly higher in the hypertensive patients than in the control group （P〈0.05）. The plasma endothelin, P-selectin levels were （95.47±5.12） pg/ ml, 42.54±3.29 in IgM positive patients, and （70.83±4.61）pg/ml, 27.47±5, 61 in IgM-negative patients in the hypertensive group, all significantly higher than （（46.93± 6.00）, 19.59 ± 4.31 in the control group （P〈0.05）. CONCLUSION Virus infection can significantly increase plasma endothelin and P-seleetin levelsin patients with hypertension, thus increasing the incidence of complications.

关 键 词：高血压 人类巨细胞病毒 感染 血浆内皮素 P-选择素 血管并发症 

分 类 号：R373[医药卫生—病原生物学]