注射用抗菌药物使用量与细菌耐药相关性研究  

Correlation analysis of usage amount of injectable antibiotics and bacterial drug resistance

作　　者：孙绪举[1] 张书勤[1] 许明旺[1] 

机构地区：[1]华中科技大学同济医学院附属梨园医院药剂科,湖北武汉430077

出　　处：《中华医院感染学杂志》2014年第15期3690-3692,共3页Chinese Journal of Nosocomiology

基　　金：湖北省卫生厅重点扶持基金资助项目(HW-2010B-101328)

摘　　要：目的对医院住院患者注射用抗菌药物使用量进行分析,并结合细菌室分离细菌监测的药敏结果对两者的相关性进行分析,为临床资料提供参考依据。方法对医院2010年1月-2012年12月住院患者注射用抗菌药物用药量进行统计,同时统计主要病原菌药敏试验结果,通过Excel软件进行汇总。结果除大环内酯类药物2011年使用量(DDDs:20487)略有下降外,其他注射用抗菌药物用量均呈逐年上升趋势,头孢菌素类用量最大(DDDs:207419),其次是喹诺酮类(DDDs:93284)和青霉素类(DDDs:88270);临床使用量呈下降趋势的头孢曲松、头孢噻肟耐药率随之降低,由于亚胺培南使用量持平,近3年未出现耐药菌株;其他抗菌药物细菌耐药率随使用量的增加而上升。结论住院患者注射用抗菌药物使用量与细菌耐药性呈正相关,采取有效措施加强对注射用抗菌药物的控制,是减少耐药菌株的有效方法。OBJECTIVE To analyze usage amount of injectable antibiotics for inpatients in our hospital and analyze the correlation of the amount and the drug susceptibility results of bacteria isolated in the bacteriology room. METHODS The medication amount of injectable antibiotics for inpatients in Jan. 2010-Dec. 2012 was statistically calculated as well as the susceptibility test results for major pathogens, data were summarized with Excel software. RESULTS Except macrolides of which usage amount （DDDs：20487） was declined slightly in 2011, the usage amount of other injectable antibiotics showed an increasing trend, including cephalosporins with the largest amount （DDDs ： 207419）, followed by quinolones （DDDs ： 93284） and penicillins （DDDs： 88270）. Clinical usage amount of the downward trend was seen for ceftriaxone, cefotaxime and their resistance rates were decreased accordingly. Resistant strains to imipenem did not appear in the recent three years as the usage amount of imipenem was flat. Resistance to other drugs was increased with the increased usage. CONCLUSION Usage amount of injectable antibiotics for inpatients was positively correlated with bacterial drug resistance, and to take effective measures to strengthen the control of antimicrobial drugs for injection is an effective way to reduce drugresistant strains.

关 键 词：住院患者 注射用 抗菌药物 使用量 细菌 耐药性 

分 类 号：R978.1[医药卫生—药品]