支原体属抗体及血清白介素-4、γ-干扰素对支气管哮喘患儿肺炎的诊断  

Mycoplasma antibodies and serum IL-4,IFN-γ for the diagnosis of pneumonia in children with bronchial asthma

作　　者：李红[1] 刘盼盼[1] 宋研研 

机构地区：[1]郑州人民医院颐和医院儿科,河南郑州450000

出　　处：《中华医院感染学杂志》2014年第15期3898-3900,共3页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(60905039)

摘　　要：目的探讨支原体抗体以及血清中白介素-4(IL-4)、γ-干扰素(IFN-γ)的检测对支气管哮喘患儿肺炎的诊断意义,为临床资料提供参考依据。方法选择医院2011年2月-2012年2月医院进行治疗的支气管哮喘患儿84例,经MP-IgM检测后分为观察组36例、对照组48例,另选择40名健康儿童作为正常健康组,分别检测3组血清IL-4、IFN-γ浓度,并进行比较分析,数据采用SPSS 16.0软件进行分析。结果观察组血清中IL-4的浓度显著高于对照组(P<0.05)与正常健康组(P<0.05),同时对照组的IL-4浓度显著高于正常健康组(P<0.05);观察组血清中IFN-γ的浓度显著低于对照组(P<0.05)与正常健康组(P<0.05),同时对照组的IFN-γ浓度显著低于正常健康组(P<0.05);IL-4与IFN-γ之间logistic回归分析结果显示,血清中的IL-4与IFN-γ为支气管哮喘患儿肺炎的主要的危险因素。结论在临床中支原体抗体、血清IL-4、IFN-γ的检测对支气管哮喘患儿肺炎的诊断具有重要意义。OBJECTIVE To explore the diagnostic significance of mycoplasma antibodies and serum IL-4, IFN-γ detection for bronchial asthma in children with pneumonia. METHODS Totally 84 children with bronchial asthma in our hospital in Feb. 2011-Feb. 2012 for treatment were selected and divided into the observation group （n=36） and the control group （n= 48） according to the MP-IgM detection. Another 40 healthy children were chosen as the normal healthy group. The three groups were detected for serum IL-4, IFN-γ concentration and were performed with comparative analysis. Data were analyzed with SPSS 16.0 software. RESULTS Serum concentrations of IL-4 was significantly higher in the observation group than in the control group （P〈0.05） and the normal healthy group （P〈0.05）. The serum IFN-y concentration was significantly lower in the observation group than in the control group （P〈0.05） and the normal healthy group （P〈0.05）, and the IFN-γ concentration was significantly lower in the control group than in the normal healthy group （P〈0.05）. The logistic regression analysis between IL-4 and IFN-γ showed that serum IL-4 and IFN-γ were significant risk factors for pneumonia in children with bronchial asthma. CONCLUSION Clinical detection of myeoplasma antibodies, serum IL-4, IFN-γ is important for diagnosis of pneumonia in children with bronchial asthma.

关 键 词：支气管哮喘 肺炎支原体 白介素一4 y-干扰素 

分 类 号：R446[医药卫生—诊断学]