超声条件下磺化杯芳烃的高效合成  

Efficient Synthesis of p-Sulfonic Acid Calixarene under Ultrasonic Irradiation

作　　者：安琳[1] 朱璇[1] 张建华[1] 朱慧东[1] 朱剑[1] 

机构地区：[1]徐州医学院药学院,江苏徐州221004

出　　处：《化学试剂》2014年第8期755-757,共3页Chemical Reagents

基　　金：江苏省高校自然科学基金资助项目(12KJB-350005);江苏省大学生科技创新课题资助项目(2011-1000);江苏高校优势学科建设工程资助项目

摘　　要：采用超声辐射，以对叔丁基杯[n]芳烃为原料，先通过逆Fridel—Crafts反应脱去叔丁基，得到杯[n]芳烃，进一步磺化，可高效制得磺化杯[n]芳烃。两步反应约0．5—1h即可完成，收率可达到90％以上。该方法较传统加热方法，操作简单，反应时间大大缩短。Under ultrasonic irradiation,p-sulfonic acid calixarene could he efficiently synthesized by using tert-hutyi calix [ n] arene as material by debutylation with AlCl3 in toluene, then sulfonation with concentrated sulfuric acid. The results showed that the reaction can be finished in only 0. 5 - 1 h and the yield was achieved to higher than 90%. The method has advantages of easy operation, short reaction time reducing and high yields.

关 键 词：超声波辐射 去叔丁基化 磺化杯芳烃 快速合成 

分 类 号：O644.3[理学—物理化学] O625.75[理学—化学]