蛇床子素微乳止痒及抗Ⅳ型变态反应的实验研究  

Experimental Study on Anti-pruritic and Anti-allergic TypeⅣ Effects of Osthole Microemulsion in Animal Models

作　　者：王永辉[1] 房树标[1] 高丽[1] 柴智[1] 周然[1] 

机构地区：[1]山西中医学院,山西太原030024

出　　处：《中华中医药学刊》2014年第8期1932-1934,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：山西省科技创新项目(2008101017);山西省科技厅科技基础条件平台建设项目(2011091014)

摘　　要：目的:观察蛇床子素微乳止痒及抗Ⅳ型变态反应的作用。方法:采用磷酸组织胺诱发豚鼠局部瘙痒、4-氨基吡啶(4-AP)诱发小鼠皮肤瘙痒及对二硝基氯苯丙(DNCB)酮溶液诱发小鼠迟发超敏反应的实验动物模型,以不同浓度的蛇床子素微乳局部外用,观察其对磷酸组织胺、4-AP致痒反应的影响和对DNCB丙酮溶液诱发迟发超敏反应的影响。结果:蛇床子素微乳局部外用可显著提高磷酸组织胺对豚鼠的致痒阈;显著抑制由4-AP所引起的小鼠皮肤瘙痒反应;显著抑制DNCB诱发的小鼠迟发超敏反应。结论:蛇床子素微乳局部外用具有良好的止痒作用和抗Ⅳ型变态反应的作用。Objective ： To study the anti - pruritic and anti - allergic type Ⅳ effects of osthole microemulsion. Methods：The anti -itching effect of osthole mieroemulsion was observed in models of histamine phosphate inducing odaxetic reaction in guinea pigs and 4 - Aminopridine （4 - AP） leading to pruritic reaction in mice. The antiallergic effect was ob-served in models of delayed hypersensitivity caused by dinitrochlorobenzene （DNCB） in mice. Results ：In anti - pruritic and antiallergic experiments ,the osthole microemulsion can obviously improve histamine acid phosphate inducing itch on guinea pig＇ s skin, restrain 4 - AP leading to pruritic reaction on the mice＇ s skin, and significantly reduce the delayed hypersensitivity caused by DNCB. Conchtsion ： Osthole microemulsion has anti - pruritic and anti - allergic effects.

关 键 词：蛇床子素 微乳 止痒作用 抗Ⅳ型变态反应 

分 类 号：R285.5[医药卫生—中药学]