高血压病对视觉随意注意影响的事件相关电位研究  

Effects of hypertension on visual voluntary attention: an event-related potentials study

作　　者：司翠平[1,2] 王鹏[1] 王秀芳[1] 王现苓 任长杰[1] 闫中瑞[1] 

机构地区：[1]山东省医学科学院附属济宁市第一人民医院神经内科,272000 [2]济南大学山东省医学科学院医学与生命科学学院

出　　处：《中华脑科疾病与康复杂志（电子版）》2014年第4期37-41,共5页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

基　　金：山东省科学发展计划(2008GG30002058)

摘　　要：目的探讨高血压对视觉随意注意的影响。方法采用视觉Oddball范式辨别任务,分析25例原发性高血压患者与25例年龄、性别、受教育年限相匹配的血压正常者的事件相关电位(ERPs)P300成分的差异,并对所有受试者采用简易智能精神状态检查量表(MMSE)进行认知功能检查。计量资料采用t检验或方差分析,相关性分析采用Pearson相关分析法。结果靶刺激诱发的视觉P300以PZ[(6.28±0.73)μV]位置波幅最大(F=4.16,P=0.02),由后向前逐渐减小[CZ:(5.53±0.71)μV,FZ:(4.48±0.77)μV];高血压组的视觉P300波幅[(4.01±0.91)μV]较正常血压组[(6.99±0.87)μV]显著降低(F=4.98,P=0.04),且在顶区最明显(F=7.72,P=0.01);高血压组[(440.75±24.46)ms]较正常血压组[(436.97±23.59)ms]的视觉P300的潜伏期延长,但差异无统计学意义(F=0.17,P=0.68);在顶区,视觉P300的波幅与MMSE评分存在显著正相关(r=0.51,P=0.01)。结论视觉随意注意以顶区激活最明显;高血压病导致视觉随意注意能力下降,且主要发生在顶区;视觉P300的波幅与MMSE存在显著正相关,波幅越高,MMSE的评分越高,提示视觉P300能为临床更早地评估高血压患者的认知功能,特别是注意功能,提供更加客观的依据。Objective To investigate the effects of hypertension on visual voluntary attention . Methods To analyze P300 component of 25 essential hypertension patients and 25 normotensives by Oddball ,and all the participants were submitted to cognitive assessment by mini -mental state examination （ MMSE） .Measurement data were analyzed by using t test and variance analysis .Correlation takes Pearson correlation analysis .Results The mean amplitude of visual P 300 elicited by target stimuli was biggest in PZ [PZ：（6.28 ±0.73）μV,CZ：（5.53 ±0.71）μV,FZ：（4.48 ±0.77）μV,F=4.16,P=0.02];Compared to contral group [（6.99 ±0.87）μV],visual P300 amplitude in hypertension group [（4.01 ±0.91）μV]was significantly declined（F=4.98,P=0.04）;The latency of visual P300 of hypertensive patients [（440.75 ± 24.46 ） ms ] was different from normal controls [ （ 436.97 ±23.59 ） ms ] , but there was no statistical significance（F=0.17,P=0.68）;The amplitude of visual P300 was positively correlated with MMSE scores （ r=0.51 , P=0.01 ） .Conclusions The distribution of visual voluntary attention wis mainly around the parietal region.Importantly, the ability of visual voluntary attention declines in hypertension patients .In addition,there is a significant positive correlation between the amplitude of visual P 300 and MMSE,which prompt visual P300 for clinical early assessment of cognitive function in patients with hypertension ,especially attention,to provide more objective basis .

关 键 词：高血压 事件相关电位 P300 视觉随意注意 

分 类 号：R544.1[医药卫生—心血管疾病]