葡醛内酯片与水飞蓟宾葡甲胺片预防抗结核药物致肝损害疗效比较及用药成本分析  

The comparison of Glucurolactone Tablets and Silybin Meglumine in the Prevention of Liver Injury Induced by Antituberculosis Drugs and the Analysis of its cost

作　　者：陈奕伸[1] 洪仲思[1] 梁嘉碧[1] 

机构地区：[1]中山大学附属第五医院,珠海519000

出　　处：《北方药学》2014年第9期20-21,共2页Journal of North Pharmacy

摘　　要：目的:通过肝功能检测指标比较葡醛内酯片与水飞蓟宾葡甲胺片预防抗结核药物致肝损害的疗效及经济性。方法:85例需门诊抗痨治疗的患者随机分为两组,A组42例应用葡醛内酯片防治药物性肝损害,B组43例应用水飞蓟宾葡甲胺片预防,每月复查肝功能指标,观察期为6个月,比较两组疗效及用药成本。结果:A、B两组对药物性肝损害的防治效果无显著差异(P>0.05)。结论:葡醛内酯片与水飞蓟宾葡甲胺片预防抗结核药物致肝损害的效果接近,但使用葡醛内酯片更加经济,有利于节省医疗费用,减轻患者负担。Objective：To observe the glucurolactone tablets and silybin meglumine in the prevention of liver injury induced by antituberculosis drugs and the analysis of its cost. Methods： 85 patients with tuberculosis in antituberculotic＇ therapy were randomly divided into two groups. Group A with 42 patients was treated with glucurolactone tablets and the group B with 45 patients was treated with silybin meglumine. The course of treatment was 6 months, after treatment their liver function was counted and compared respectively.Results： There was no significant difference between two groups （P〉0.05）. Conclusion： there was the same effec＇,t between glueurolactone tablets and silybin meglumine in the prevention of liver injury induced by antituberculosis drugs, but glucurolactone tablets in lower cost. So, the use of glueurolactone tablets can reduce the economic burden of the patiens.

关 键 词：葡醛内酯片 水飞蓟宾葡甲胺片 抗痨 药物性肝损害 

分 类 号：R978.3[医药卫生—药品]