小儿支原体肺炎炎性指标检查及临床意义  

The Examination of Inflammatory Indicators and Clinical Significance in Children with Mycoplasm Pneumonia

作　　者：陈琼[1] 万耕宏 徐秀娟[1] 黄志[1] 

机构地区：[1]重庆医科大学附属儿童医院,儿童发育疾病研究教育部重点实验室,儿科学重庆市重点实验室,重庆市儿童发育重大疾病诊治与预防国际科技合作基地,重庆400014

出　　处：《儿科药学杂志》2014年第8期1-4,共4页Journal of Pediatric Pharmacy

摘　　要：目的:检测不同年龄组肺炎支原体肺炎(MPP)患儿WBC、CRP、PCT水平的变化情况,分析不同年龄组患儿MP的药敏情况,探讨其临床意义。方法:对已确诊为MPP的108例患儿按年龄分为婴幼儿组、学龄前期组和学龄期组,检测血中WBC、CRP和PCT水平,分别比较各项指标在不同年龄的差异,同时分析各组患儿对阿奇霉素、喹诺酮类与红霉素的敏感性。结果:各年龄组患儿WBC、CRP和PCT水平均有升高,两两比较差异有统计学意义(P<0.05)。婴幼儿组与学龄前期组、婴幼儿组与学龄期组、学龄前期组与学龄期组患儿MP对阿奇霉素、喹诺酮类、红霉素药敏情况比较差异无统计学意义(P>0.05);阿奇霉素与红霉素、喹诺酮类与红霉素各年龄组药敏情况比较差异有统计学意义(P<0.05)。各年龄组患儿MP对阿奇霉素和喹诺酮类抗菌药物均较敏感,而对红霉素的敏感性则较低。结论:对于MPP患儿应及时行CRP、PCT和WBC检测,早期使用阿奇霉素治疗小儿MPP,可以有效提高治疗效果。Objective： To investigate the variations of WBC, CRP and PCT in children with mycoplasm pneumoniae pneumonia （MPP） and study the drug susceptibility of MP in different age groups and explore their clinical values. Methods： One hundred and eight MMP children were divided into infants, preschool and school-age groups by age. The levels of blood WBC, CRP and PCT were detected in each group and the differences were compared respectively. We also analyzed the children＇ s sensitivity to three different drugs including azithromycin, quinolone and erythromycin. Results： The levels of WBC, CRP and PCT in all groups were increased. The differences of WBC, CRP and PCT levels between infants and preschool group, infants and school-age group, preschool and school-age group were significant （P〈0. 05 ）. The sensitivities to azithromycin, quinolone and erythromycin were the same compared respectively between infants and preschool groups, infants and school-age groups, preschool and school-age groups. In each group the drug sensitivities between erythromyein and quinolone were significantly different. So were the sensitivities between erythromyein and azithromyein. MPP children in all groups were more sensitive to azithromycin and quinolone than erythromycin. Conclusions： For children with MPP early tests of CRP, PCT and WBC are needed. And the early use of azithromycin treatment of children with mycoplasma pneumonia, can effectively improve the curative effect of children.

关 键 词：肺原支原体 肺炎 C反应蛋白 降钙素原 阿奇霉素 

分 类 号：R725.6[医药卫生—儿科]