环肺静脉消融联合去迷走神经化治疗心房颤动的临床研究  

Circumferential ablation of pulmonary vein ostium combined with vagal denervation for the treatment of atrial fibrillation: a clinical study

作　　者：于宏颖[1] 潘震华[1] 李艳红[1] 邢丽娜[1] 黎辉[1] 

机构地区：[1]黑龙江省大庆油田总医院心内科四病区,163001

出　　处：《介入放射学杂志》2014年第7期569-571,共3页Journal of Interventional Radiology

摘　　要：目的观察环肺静脉消融电隔离术治疗阵发性心房颤动(房颤),术中出现去迷走效应(vagal denervation,VD)对疗效的影响。方法对50例阵发性房颤患者行环肺静脉射频消融术(RFA)治疗,消融终点为肺静脉电隔离,将术中出现去迷走效应并进行消融的房颤患者列为VD阳性组(19例),余患者列为VD阴性组(31例)。观察比较两组患者术后6个月房颤的复发率。结果 50例均达消融终点,术后6个月,VD阳性组疗效明显高于VD阴性组(84.21%比64.511%,P≤0.05)。结论环肺静脉消融术治疗房颤过程中发生去迷走效应可明显提高房颤RFA的的成功率。Objective To evaluate the impact of vagal denervation （VD） that is derived from circumferential ablation of pulmonary vein ostium for paroxysmal atrial fibrillation （AF） on the therapeutic results. Methods A total of 50 patients with paroxysmal atrial fibrillation were enrolled in this study. Circumferential ablation of pulmonary vein ostium was carried out in all the patients. The end point of ablation was pulmonary vein electricity isolation. The patients in whom VD occurred during the performance of ablation were regarded as VD- positive group （n = 19）, and the remaining patients were used as VD- negative group （n = 31）. The recurrence rate of AF six months after the treatment was recorded, and the results were compared between the two groups. Results The end point of ablation was successfully achieved in all the fifty cases. Six months after the ablation, the therapeutic effect of VD- positive group was significantly better than that of VD- negative group （84.21% vs 64.51%, P ≤ 0.05）. Conclusion The vagal denervation effect that is derived from circumferential ablation of pulmonary vein ostium in treating AF can significantly increase the success rate of radiofrequency ablation for AF.

关 键 词：心房颤动 肺静脉 导管消融 去迷走效应 

分 类 号：R541.75[医药卫生—心血管疾病]