组织多普勒右室Tei指数评价肺动脉高压模型兔右室功能的实验研究  

Experimental study of Tissue Doppler Tei index in the evaluation of right ventricular function in a rabbit model of pulmonary

作　　者：王静[1] 张健[1] 范小明[1] 韩建一[1] 王海鹏[2] 屈百鸣[2] 

机构地区：[1]浙江省人民医院超声科,浙江杭州310014 [2]浙江省人民医院心内科,浙江杭州310014

出　　处：《医学影像学杂志》2014年第7期1243-1246,共4页Journal of Medical Imaging

摘　　要：目的探讨超声心动图组织多普勒Tei指数在评价肺动脉高压模型兔右心功能方面的应用价值,并分析尼可地尔对肺动脉高压所致的右心功能减退是否有缓解作用。方法研究对象为33只雄性新西兰白兔随机分为三组:I组,肺动脉高压模型组(肺动脉收缩压>30mmHg);II组,尼可地尔组;III组,空白对照组(肺动脉收缩压≤30mmHg)。对所有模型测定右心功能超声指标,比较各组间指标的差别,分析右室Tei指数对右心功能的影响。取标准心尖四腔观,测量右室收缩期右房室环最大运动速率(Sm)、舒张早期最大运动速率(Em)、舒张晚期最大运动速率(Am)和Em/Am值,以及ET,计算右室Tei指数。结果肺高压组(I组)右室Em下降,Am增高,Em/Am比值降低。与正常对照组(III组)相比,肺高压组(I组)右室Tei指数明显升高(P<0.01),与正常对照组(III组)相比,尼可地尔组(II组)右室Tei指数明显升高(P<0.01)。肺高压组(I组)与尼可地尔组(II组)相比,肺高压组(I组)Tei指数较高,差异有统计学意义(P<0.05)。结论利用TDI技术测量右心Tei指数对右心功能不全患者可无创、迅速地评价其右心室功能,对指导临床治疗具有较高的应用价值。尼可地尔对改善由肺动脉高压导致的右心功能减退亦有一定的疗效。Objective To investigate the application value of tissue Doppler echocardiography Tei index in the evaluation of right heart function in a rabbit model of pulmonary hypertension,and to analyze whether nicorandil had a relief effect on pulmonary hypertension caused by right ventricular dysfunction.Methods The subjects were〉 33 male New Zealand white rabbits,which were randomly divided into three groups：group I,pulmonary hypertensive model group,（pulmonary artery systolic pressure30mmHg）;group II,nicorandil-treated group;group III,blank control group（pulmonary vasoconstriction pressure≤30mmHg）.The parameters of echocardiography regarding the right ventricular function for for all models were detected,the differences of these indicators between the groups were compared,and the effects of right ventricular Tei index on right ventricular function were analyzed.The standard apical four-chamber view were taken,the maximum movement velocity（Sm）of right atrioventricular ring at right ventricular systolic stage,the maximal exercise（Em）at early diastolic stage,the maximum moving speed（Am）at late diastolic stage,and the Em/Am values were measured.Also,ET and right ventricular Tei index were calculated Results In group I,Em was decreased,Am was increased,and Em/Am ratio was decreased.Compared with that in group III,the right ventricular Tei index in group I was significantly higher（P〈0.01）and compared with that in group III,the right ventricular Tei index in group II was significantly higher（P〈0.01）.Compared with that in group II,the Tei index in group I was higher,the difference was statistically significant（P〈0.05）.Conclusion TDI technology for measuring right ventricular Tei index in patients with right ventricular dysfunction may be noninvasive,which can rapidly evaluate right ventricular function and has a high application value in clinical treatment.Nicorandil has a certain effect on improving pulmonary hypertension caused by a right heart dysfunction.

关 键 词：肺动脉高压 右心室功能 组织多普勒成像 超声心动描记术 TEI指数 

分 类 号：R543.2[医药卫生—心血管疾病] R445.1[医药卫生—内科学]