他汀类药物安全性研究进展  

Research progress in the safety of statins

作　　者：张晓春[1] 管丽华[1] 潘文志[1] 李明飞[1] 常晓鑫 周达新[1] 

机构地区：[1]复旦大学附属中山医院心内科,上海市心血管疾病研究所,上海200032

出　　处：《上海医药》2014年第15期6-8,17,共4页Shanghai Medical & Pharmaceutical Journal

基　　金：上海市科学技术委员会自然科学基金项目(项目编号:07ZR14024)

摘　　要：他汀类药物是一类临床应用广泛的口服降脂药物,主要用于降低血浆中的低密度脂蛋白胆固醇水平。大量的研究已经确定了他汀类药物在心血管、脑血管和代谢性疾病治疗中的临床地位,尤其在心、脑血管疾病的一级和二级预防中发挥着重要作用。他汀类药物还可能具有抑制肾脏细胞增殖、抗肿瘤、抗炎、治疗骨质疏松、预防痴呆和免疫抑制等作用。随着他汀类药物的广泛应用以及相关国际指南推荐长期不间断地用药,了解其短期及长期不良反应对临床实践具有重要的意义。本文总结他汀类药物的安全性研究资料,以期为临床合理用药提供参考。Statins are a sort of widely used oral lipid-lowering drugs in clinic, which are mainly used for reducing the level of low-density lipoprotein cholesterol in plasma. The role of statins in the treatment of cardiovascular, cerebrovascular and metabolic diseases has been verified by a lot of research work, especially its important role in primary and secondary prevention for the cardiovascular and cerebrovascular diseases. Statins can also be used for the inhibition of renal cell proliferation, antitumor, anti-inflammatory therapy and for the treatment of osteoporosis, prevention of dementia and immunosuppression. With the widespread use of statins, and long-term continuous medication recommended by international guidelines, it is significant to understand the adverse reactions of short-term and long-term in our daily clinical practice. Data on the safety research of statins are summarized so as to provide references for clinical medication.

关 键 词：他汀类药物 药品不良反应 肝毒性 肌肉损害 

分 类 号：R972.6[医药卫生—药品]