冠心病患者CRP、CysC等生化检验指标的测定及其临床意义  

Determination of biochemical indicators such as CRP and CysC in patients with coronary heart disease and their clinical significance

作　　者：谭晓彬[1] 张铨玫 

机构地区：[1]赣南医学院第一附属医院检验科 [2]赣南医学院第一附属医院药剂科,赣州341000

出　　处：《上海医药》2014年第15期46-48,共3页Shanghai Medical & Pharmaceutical Journal

基　　金：2011年江西省卫生厅科研计划课题2011A120

摘　　要：目的:探讨冠心病患者血清C反应蛋白(CRP)、胱抑素C(CysC)等生化检验指标测定的临床意义。方法:选取2011年2月-2013年2月在本院就诊的80例冠心病患者作为观察组[其中急性心肌梗死(AMI亚组)33例,不稳定型心绞痛(UAP亚组)23例,稳定型心绞痛(SAP亚组)24例],将同期80例健康体检者作为对照组,采用生化分析仪检测全部受试对象的生化检验指标,包括:血清C反应蛋白(CRP)、胱抑素C(CysC)、同型半胱氨酸(Hcy)、血糖(GLU)、总蛋白(TP)、尿素氮(BUN)、肌酐(Cr)等,并进行统计学分析。结果:两组受试者的GLU、TP、BUN、Cr指标差异无统计学意义(P>0.05),但观察组患者CRP、CysC、Hcy水平明显高于对照组(P<0.05)。在不同类型冠心病的比较中发现AMI亚组患者血清Hcy和CRP水平明显高于UAP亚组和SAP亚组(P<0.05)。AMI组亚患者血清CysC水平明显低于UAP亚组和SAP亚组(P<0.05)。结论:CRP、CysC、Hcy水平的检测可以作为预测冠心病的发生和发展的指标,值得临床推广使用。Objective： To explore the clinical significance of the determination of biochemical indicators such as serum C-reactive protein （CRP）, cystatin C （CysC） in patients with coronary heart disease （CHD）. Methods： Eighty patients with coronary heart disease were selected as an observation group including AMI subgroup 33 cases, UAP subgroup 23 cases and SAP subgroup 24 cases, and 80 people with healthy examination as a control group. Biochemical indicators including CRP, CysC, homocysteine （Hcy）, glucose （GLU）, total protein （TP）, blood urea nitrogen （BUN）, creatinine （Cr） were detected in all subjects by biochemical analyzer, and were statistically analyzed. Results： There were no statistically significant differences in GLU, TP, BUN, Cr indicators between two groups （P〉0.05） while CRP, CysC, Hcy levels were obviously higher in the observation group than in the control group （P〈0.05）. In a comparison of different type of CHD, serum Hcy and CRP levels of patients were significantly higher in AMI subgroup than in UAP and SAP subgroups （P〈0.05） while serum CysC level was lower in AMI subgroup than in UAP and SAP subgroups （P〈0.05）. Conclusion： Determination of CRP, CysC, Hcy levels can be used as indicators for the prognosis of the occurrence and development of coronary heart disease, which is worthy of clinical use.

关 键 词：冠心病 血清C反应蛋白 胱抑素C 生化检验指标 

分 类 号：R446.11[医药卫生—诊断学] R541.4[医药卫生—临床医学]