种植体周围炎时的白细胞介素17:是骨保护还是骨破坏?  

Interleukin-17 in peri-implantitis: bone protector or destroyer?

作　　者：刘博[1] 宋宁[2] 步捷[1] 封伟[3] 

机构地区：[1]济宁医学院口腔医学系,山东省济宁市272067 [2]四川大学华西口腔医学院,四川省成都市610041 [3]济宁医学院附属医院口腔科,山东省济宁市272029

出　　处：《中国组织工程研究》2014年第25期4062-4067,共6页Chinese Journal of Tissue Engineering Research

基　　金：济宁医学院2013年度校级科研计划项目(JY2013KJ018)资助~~

摘　　要：背景:种植体周围炎发生时,种植体周围龈沟液和软组织中的白细胞介素17水平明显增加,并与种植体周围探诊深度呈正相关关系,但由于白细胞介素17的骨吸收和保护的双重作用,在种植体周围炎中的作用存在争议,尚有待进一步深入研究。目的:回顾性探讨种植体周围炎和白细胞介素17相关性的研究进展。方法:由第一作者用计算机检索万方数据库、中国知网(CNKI)、Medline数据库,检索时间:1991至2014年,检索词为"牙种植体,种植体周围炎,牙周炎,Th17细胞,白细胞介素17,细胞因子"和"dental implants,peri-implantitis,periodontitis,Th17 cells,interleukin-17,cytokines",语言分别设定为中文和英文。从白细胞介素17在种植体周围炎中骨破坏和骨保护两方面作用进行总结,对种植体周围炎中白细胞介素17的检测、表达及与炎症程度相关性等方面进行讨论。结果与结论:共检索到文献241篇,按照纳入与排除标准对文献进行筛选,共纳入46篇。结果表明利用种植体周围龈沟液或者血液,无创性的检测白细胞介素17水平变化,有利于种植体周围炎的早期诊断和治疗效果监测。目前大部分研究显示白细胞介素17和种植体周围炎有一定联系,白细胞介素17水平和种植体周围探诊深度呈正相关关系。但是,也有部分研究推测白细胞介素17有骨保护作用,白细胞介素17受体基因水平在慢性牙周炎和牙周健康者中的差异无显著性意义。鉴于此,种植体周围炎和白细胞介素17的相关性尚有待进一步研究。BACKGROUND：When peri-implantitis occurs, the levels of interleukin-17 in the peri-implant sulcular fluid and soft tissues are significantly increased, and there is a positive correlation with the depth of the peri-implant probing. However, because of the dual effects of bone absorption and protection, the function of interleukin-17 in peri-implantitis remains controversial, which should be further studied. OBJECTIVE：To retrospectively analyze the correlation between peri-implantitis and interleukin-17. METHODS： The first author searched Wanfang, CNKI and Medline databases from 1991 to 2014 by using key words of “dental implants, peri-implantitis, periodontitis, Th17 cels, interleukin-17, cytokines” in Chinese or English. The functions of bone destruction and protection of interleukin-17 in peri-implantitis were reviewed, andinterleukin-17 expression and correlation with the peri-implantitis were detected. RESULTS AND CONCLUSION：According to the inclusion and exclusion criteria, 46 articles from 241 articles are selected. The results show that, noninvasive detection of the variation of interleukin-17 levels in peri-implant sulcular fluid or blood is conducive to the monitoring of early diagnosis and treatment of peri-implantitis. At present, most researches show the relationship between interleukin-17 and peri-implantitis, and there is a positive correlation between interleukin-17 and peri-implant probing depth. But other researches suggest that interleukin-17 acts as protector for bones, and there is no statistic significance in the level of interleukin-17 receptor gene in chronic peri-odontitis and healthy subjects. Therefore, the correlation between peri-implantitis and interleukin-17 remains to be further studied.

关 键 词：生物材料 口腔生物材料 牙种植体 种植体周围炎 牙周炎 TH17细胞 白细胞介素17 细胞因子 

分 类 号：R318[医药卫生—生物医学工程]