妇科门诊宫颈糜烂患者1980例HPV感染状况分析  

HPV Infection in 1980 Cases of Cervical Erosion in Gynecological Clinic

作　　者：赵东岩[1] 侯霞[1] 陈弟[1] 邓德耀[1] 刘春林[1] 高宗鹰[1] 

机构地区：[1]云南省第二人民医院检验科,云南昆明650021

出　　处：《中国皮肤性病学杂志》2014年第8期814-816,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的分析本院2011-2012年度妇科门诊宫颈糜烂患者中高危型和低危型人乳头瘤病毒(HPV)的感染情况,为宫颈癌的预防提供依据。方法利用荧光定量PCR技术对1 980例样本进行HPVDNA检测,数据用SPSS软件进行分析。结果 1 980例宫颈糜烂患者样本中,检出高危型HPV(16,18,31,33,45,52,56,58)感染431例,感染率21.77%;低危型HPV(6,11)感染145例,感染率7.32%,双重感染共计36例,占感染总人数的6.67%,25岁以前年龄组和55岁以后年龄组高危HPV感染率明显增高,特别是前者与其他年龄组比较差异有统计学意义(P<0.05)。重度糜烂组高危HPV感染率高达32.26%。结论本地区宫颈糜烂患者中HPV感染率较高,以高危型HPV为主,有明显的年龄分布特征,在重度糜烂组高危HPV感染率明显增高,高危型HPV是宫颈癌的明确病因,对宫颈糜烂患者进行HPV检测跟踪,对宫颈癌的预防和治疗有积极意义。Objective To study of cervical erosion in gynecological clinic patients with high-risk and low-risk human papillomavirus infection in our hospital from 2011 to 2012, and provide the basis for the prevention of cer- vical cancer. Methods The 1 980 cases of HPV infection samples were detected by the fluorescence quantitative PCR, and the results were analyzed using SPSS software. Results Four hundred and thirty- one cases （21.77%） were positive for high-risk HPV（ 16,18,31,33,45,52,56,58 ）, one hundred and fourty-five cases （7.32%） positive for low-risk HPV. Thirty-six cases of samples （6. 67% ）were positive for both high-risk and low-risk HPV infection. The high-risk HPV was susceptibly for the age group of be- fore the age of 25 and after the age of 55, especially the former had significant difference when compared with other age groups（P 〈0. 05）. High-risk HPV infection rate was 32. 26% in the severe clinical ero- sions group. Conclusion HPV infection rate was higher in patients with cervical erosion in the region, featured by the priority of high risk type and age distribution. High-risk HPV infection rates was signifi- cantly higher in the severe erosion group, which is an identified cause of cervical cancer. To detect of HPV infection and follow-up examination for the patients with cervical erosion could be useful for the prevention and treatment of cervical cancer.

关 键 词：宫颈糜烂 人乳头瘤病毒 宫颈癌 荧光定量PCR 

分 类 号：R711.32[医药卫生—妇产科学] R737.33[医药卫生—临床医学]