头孢哌酮/舒巴坦联合米诺环素治疗鲍氏不动杆菌感染的疗效评价  

Effect of cefoperazone sulbactam combined with minocycline in the treatment of Acinetobacter baumannii infections

作　　者：郑芝欣[1] 魏简汇[1] 王书芬[1] 

机构地区：[1]南阳市中心医院药剂科,河南南阳473001

出　　处：《中华医院感染学杂志》2014年第16期3958-3960,共3页Chinese Journal of Nosocomiology

基　　金：河南科技厅重点基金资助项目(PY8906UYP)

摘　　要：目的研究头孢哌酮/舒巴坦联合米诺环素治疗鲍氏不动杆菌感染中的疗效,为临床用药提供参考依据。方法选择2011年9月-2013年9月住院治疗并给予头孢哌酮/舒巴坦联合米诺环素治疗鲍氏不动杆菌感染患者132例,分析鲍氏不动杆菌感染的科室分布、临床疗效及不良反应发生,采用SPSS13.0进行分析。结果鲍氏不动杆菌感染患者主要分布在ICU、胸外科、呼吸科等科室,分离标本以痰液、创面分泌物等为主;鲍氏不动杆菌对米诺环素和头孢哌酮/舒巴坦具有较高的敏感率,分别为100.00%、73.48%;头孢哌酮/舒巴坦联合米诺环素治疗鲍氏不动杆菌感染的治疗有效率为73.49%、细菌清除率为35.61%;患者治疗过程中有12例出现恶心、腹泻或皮疹等不良反应,发生率为10.43%,均未影响药物治疗。结论头孢哌酮/舒巴坦联合米诺环素用于治疗鲍氏不动杆菌所致感染,具有安全、有效的特点。OBJECTIVE To study the effect of cefoperazone sulbactam combined with minocycline in the treatment of Acinetobacter baumannii infections,so as to provide the reference for clinic.METHODS A total of 132 patients with A.baumannii infections given cefoperazone sulbactam plus minocycline treatment were selected in our hospital.The A.baumannii distribution,separation,clinical effect and adverse reaction incidence were analyzed.SPSS13.0 software was used for statistical analysis.RESULTS The patients were mainly distributed in ICU,department of thoracic surgery,department of respiration.A.baumannii was isolated from sputum and wound secretions and it showed high susceptibility to minocycline and cefoperazone sulbactam,the value of which were100% and 73.48%.The therapeutic effect rate was 73.49%,the bacterial eradication rate was 35.61%.Nausea,diarrhea and rash observed in 12 patients,the incidence rate was 10.43% which had not affected to medicine treatment.CONCLUSION Cefoperazone sulbactam combined with minocycline for the treatment of A.baumannii infection is safe and effective.

关 键 词：头孢哌酮 舒巴坦 米诺环素 鲍氏不动杆菌 临床疗效 

分 类 号：R978.1[医药卫生—药品]