降钙素原与C-反应蛋白对骨折患者术后感染的诊断价值分析  

The diagnostic value of procalcitonin and C-reactive protein for postoperative infection in patients with fracture

作　　者：杨国虎[1] 蒋丽媛[1] 高正君[1] 

机构地区：[1]甘肃省人民医院整形科,甘肃兰州730000

出　　处：《中华医院感染学杂志》2014年第16期4150-4151,4154,共3页Chinese Journal of Nosocomiology

基　　金：甘肃省自然科学基金资助项目(ZR-96-078)

摘　　要：目的探讨血清降钙素原(PCT)、C-反应蛋白(CRP)对整形科收治的骨折术后修复患者感染的诊断价值,以期为骨折患者术后感染预防提供可靠的科学依据。方法 2011年4月-2013年4月整形科收治的骨折术后修复的127例患者作为研究对象,其中发生感染患者21例作为感染组,其他无感染的106例患者作为对照组,于术前术后进行CRP、PCT连续检测,采用SPSS17.0进行分析。结果 127例患者中发生感染21例,感染率为16.54%;术前检查CRP、PCT感染组分别为(10.4±5.8)mg/L、(0.3±0.1)μg/L,非感染组分别为(10.6±5.7)mg/L、(0.3±0.1)μg/L,组间差异无统计学意义,术后第1天感染组CRP、PCT分别为(52.5±23.1)mg/L、(1.3±0.4)μg/L,非感染组分别为(16.8±6.4)mg/L、(0.4±0.1)μg/L,两组均高于术前水平,且感染组明显高于对照组(P<0.05);术后第3天检测结果显示感染组CRP、PCT持续升高,与术前比较差异有统计学意义,而非感染组明显降低,与术前比较差异无统计学意义。结论 CRP、PCT对骨折术后修复感染的诊断更具有时效性,为早期诊断预防性治疗提供有效的参考价值。OBJECTIVE To investigate the diagnostic value of plasma procalcitonin（PCT）,C-reactive protein（CRP）for postoperative infection in patients with fracture in the department of plastic surgery,in order to provide reliable scientific evidence for preventing postoperative infection in patients with fracture.METHODS Totally 127 patients undergoing repair surgery for fracture in our hospital from Apr.2011-Apr.2013 were selected for prospective study,including 21 patients with infection as the infection group,the other 106 patients without infection as the control group.Preoperative and postoperative CRP,and PCT were continuously detected.Data were analyzed with SPSS17.0.RESULTS There were 21 infected cases（the infection rate 16.54%）in the 127 patients.The preoperative CRP,PCT were（10.4±5.8）mg/L,（0.3±0.1）μg/L in the infection group,and（10.6±5.7）mg/L,（0.3±0.1）μg/L in the non-infection group,with no significant difference between the groups（P0.05）.The CRP,PCT at the first postoperative day were（52.5±23.1）mg/L,（1.3±0.4）μg/L in the infection group,and（16.8±6.4）mg/L,（0.4±0.1）μg/L in the non-infection group,which were all higher than the preoperative levels,and the levels in the infection group was significantly higher than in the control group（P0.05）.The test results at postoperative 3days showed that the CRP,PCT in the infection group continued to rise,differences were significant compared with the preoperative levels,however,the levels were significantly decreased in the control group,the difference was not significant compared with preoperation（P0.05）.CONCLUSION CRP and PCT for the diagnosis of infection after fracture repair are timelier.For the early diagnosis and preventive therapy,they have an effective reference value.

关 键 词：降钙素原 C-反应蛋白 骨折 术后感染 诊断价值 

分 类 号：R446[医药卫生—诊断学]