替普瑞酮联合奥美拉唑对胃良性溃疡愈合质量的影响  

Influence of Teprenone Combined with Omeprazole on Healing Quality of Benign Gastric Ulcer

作　　者：卢英军 李树义[1] 王静[1] 

机构地区：[1]河北省唐山市第九医院,河北唐山063000

出　　处：《中国药业》2014年第15期27-29,共3页China Pharmaceuticals

摘　　要：目的探讨胃黏膜保护剂替普瑞酮对胃溃疡患者愈合质量的影响。方法将177例胃溃疡患者随机分为对照组88例和观察组89例。对照组患者给予替普瑞酮治疗,观察组患者给予奥美拉唑联合替普瑞酮治疗,随访1年,比较两组患者的临床疗效、胃溃疡的愈合质量、不良反应及复发情况。结果观察组患者治疗总有效率为97.75%,明显高于对照组的89.77%(P<0.05);S2期获得率观察组为66.29%,明显高于对照组的27.27%(P<0.05);观察组患者恶心、腹痛、腹泻、皮疹发生率均分别高于对照组,出血发生率低于对照组,但差异均无统计学意义;观察组患者溃疡复发率明显低于对照组(P<0.05)。结论胃黏膜保护剂替普瑞酮与质子泵抑制剂奥美拉唑联用可明显提高胃良性溃疡的治愈率,不良反应少且安全性高,还可显著降低复发率,值得临床推广。Objective To investigate influence of gastric mucosal protective agent teprenone the healing quality of benign gastric ulcer. Methods 177 patients with benign gastric ulcer were randomly divided into the control group（88 cases） and the observation group（89 cases） . The control group was given teprenone and the observation group was given omeprazole combined with teprenone. The patients were followed up for 1 year. The clinical effect, gastric ulcer healing quality, adverse reactions and recurrence were compared between two groups. Results The total effective rate in the observation group was 97. 75% , which was significantly higher than 89. 77% in the con-trol group（ P ﹤ 0. 05）; the S2 - stage shift rate in the observation group was 66. 29% , which was significantly higher than 27. 27% in the control group（ P ﹤ 0. 05）. The occurrence rate of nausea, abdominal pain, diarrhea and skin rash in the observation group was higher than that in the control group, but the bleeding rate in the observation group was lower than that in the control group, the differences had no statistically significant; the recurrence rate in the observation group was significantly lower that that in the control group（ P ﹤ 0. 05）. Conclusion The combination of the gastric mucosal protective agent teprenone and the proton pump inhibitor omeprazole can obviously increase the cure rate, has less adverse reactions and high safety, can apparently decrease the recurrence rate, which is worthy of clinical promotion.

关 键 词：替普瑞酮 奥美拉唑 胃溃疡 愈合质量 

分 类 号：R969.4[医药卫生—药理学] R975.6[医药卫生—药学]