罗库溴铵与顺式阿曲库铵用于气管插管中肌肉松弛恢复情况对比  

Clinical Comparative Study on Rocuronium and Cisatracurium for Muscle Relaxation Recovery in Endotracheal Intubation

作　　者：刘龙娟 梁良 

机构地区：[1]陕西省铜川矿务局中心医院,陕西铜川727000

出　　处：《中国药业》2014年第15期89-90,共2页China Pharmaceuticals

摘　　要：目的观察顺式阿曲库铵和罗库溴铵对肌肉松弛情况和气管插管条件下的效果。方法将162例行全身麻醉气管插管腹部手术的患者随机分为对照组和观察组,各81例,经静脉注入咪达唑仑0.04 mg/kg,芬太尼3μg/kg进行麻醉诱导,待患者意识和睫毛反射消失后,对照组给予罗库溴铵0.5 mg/kg,观察组给予顺式阿曲库铵0.12 mg/kg后行气管插管,使用七氟烷维持麻醉深度。比较气管插管的总有效率、两组患者术前和术后平均动脉压(MAP)、血氧饱和度(SpO2)和心率(HR)的变化,记录肌肉松弛的起效时间、作用时间、恢复指数及不良反应情况。结果观察组气管插管总有效率为96.30%,显著高于对照组的90.12%(Z=2.83,P<0.05);两组患者术后的MAP、HR和SpO2与术前相比差异不明显;观察组的肌肉松弛起效时间较长,但作用时间和恢复指数均明显低于对照组(P<0.05);观察组不良反应情况少于对照组,但差异无统计学意义。结论顺式阿曲库铵用于全麻气管插管术的持续时间短,恢复迅速,不良反应少,是临床较理想的肌肉松弛药。Objective To investigate the effect of cisatracurium and rocuronium for tracheal intubation condition and muscle relaxation. Methods 162 patients with abdominal operation under general anesthesia endotracheal intubation were randomly divided into the obser-vation group and the control group, 81 cases in each group, and intravenously injected by midazolam 0. 04 mg / kg, fentanyl 3 μg / kg for anesthesia induction. Then after the patients＆#39; consciousness and eyelash reflex disappearance, the control group was given rocuroni-um 0. 5 mg / kg and the observation group was given cisatracurium 0. 12 mg / kg. Then the endotracheal intubation was performed and sevoflurane was used for maintaining the anesthesia depth. The total effective rates of endotracheal intubation and the changes of MAP, SPO2 and HR before and after operation were compared between the two groups. Besides, the muscle relaxation onset time, ef-fective time, recovery index and adverse reactions were also recorded. Results The total effective rate of endotracheal intubation was 96. 30% in the observation group and 90. 12% in the control group with statistically significant difference between the two groups （ Z = 2. 83, P ﹤ 0. 05 ） ; MAP, SpO2 and HR after operation in the two groups had no obvious difference compared with before opera-tion; the muscle relaxation onset time in the observation group was longer, but the action time and the recovery index were signifi-cantly lower than those in the control group with statistical differences（ P ﹤ 0. 05 ） ; the adverse reaction situation in the observation group was less than that in the control group without statistical difference. Conclusion Cisatracurium used in endotracheal intubation has short persistent time, rapid recovery, fewer adverse reactions and is a more ideal muscle relaxant.

关 键 词：肌肉松弛 气管插管 顺式阿曲库铵 罗库溴铵 起效时间 

分 类 号：R969.4[医药卫生—药理学] R971.2[医药卫生—药学]