冷沉淀治疗脑外伤后血凝功能障碍患者34例临床研究  

Clinical Efficacy of Cryoprecipitate in Treating Coagulopathy after Traumatic Brain Injury in 34 Cases

作　　者：冉毅[1] 程强[1] 熊海兵[1] 

机构地区：[1]重庆市巴南区人民医院神经外科,重庆401320

出　　处：《中国药业》2014年第15期125-126,共2页China Pharmaceuticals

摘　　要：目的分析脑外伤后凝血功能障碍患者早期应用冷沉淀的疗效,探讨冷沉淀在脑外伤诊治的应用。方法将64例脑外伤伴凝血功能障碍患者随机分为治疗组34例和对照组30例。对照组患者予常规止血、脱水、预防癫痫、营养神经、预防癫痫及对症治疗,治疗组患者加用冷沉淀止血。统计并分析进展性脑出血的发生率、凝血指标及患者的预后。结果治疗组进展性脑出血的发生率为17.65%,明显低于对照组的30.00%(P<0.05)。治疗组患者输冷沉淀后凝血指标有明显改善(P<0.05),患者预后比对照组更好(P<0.05)。结论冷沉淀能改善凝血功能障碍,减少进展性脑出血的发生,最终改善患者预后。Objective To analyze the effect of early using cryoprecipitate in treating coagulopathy after traumatic brain injury and to in-vestigate its application in the diagnosis and treatment of brain trauma. Methods 64 patients with traumatic brain injury complicating coagulopathy were randomly divided into the therapy group（34 cases） and the control group（30 cases） . The control group were treated with the conventional therapy of hemostasis, dehydration, preventing epilepsy, trophic nerve and symptomatic treatment, the therapy group was added with cryoprecipitate on the basis of conventional therapy. The occurrence rate of progressive cerebral hemorrhage, coagulation indexes and prognosis were statistically analyzed and compared between the two groups. Results The occurrence rate of progressive cerebral hemorrhage was 17. 65% in the therapy group, which was significantly lower than 30. 00% in the control group（ P ﹤ 0. 05）; the coagulation indexes after treatment in the therapy group were obviously improved than before treatment（ P ﹤ 0. 05）; the therapy group had better prognosis than the control group（ P ﹤ 0. 05 ） . Conclusion Cryoprecipitate can improve coagulopathy, reduce the occurrence of progressive cerebral hemorrhage and ultimately improve the patients＆#39; prognosis.

关 键 词：冷沉淀 脑外伤 凝血功能障碍 进展性脑出血 

分 类 号：R969.4[医药卫生—药理学] R977.6[医药卫生—药学]