胱抑素C、β2-微球蛋白及尿微量清蛋白在早期肾损害诊断中的应用价值分析  

Value analysis of cystatin C, β2-microglobulin and microalbuminuria in the diagnosis of early renal damage

作　　者：许苏琴 张萍[2] 

机构地区：[1]浙江省义乌复元私立医院检验科,浙江义乌322000 [2]浙江大学医学院附属第一医院肾脏病科,浙江杭州310003

出　　处：《中国现代医生》2014年第23期158-160,共3页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2011RCB020)

摘　　要：目的分析胱抑素C、β2-微球蛋白及尿微量清蛋白在早期肾损害诊断中的应用价值。方法选取我院泌尿科收治的150例早期肾损害患者作为观察组,选取来我院体检的150名正常成年人作为对照组,测定两组的胱抑素C、β2-微球蛋白及尿微量清蛋白并进行对比,同时对比三种标志物单独或联合检测的诊断价值。结果观察组患者的胱抑素C、β2-微球蛋白及尿微量清蛋白水平均要明显高于对照组,胱抑素C、β2-微球蛋白、尿微量清蛋白与联合检测的灵敏度分别为91.33%、88.00%、94.00%与98.00%;特异性分别为88.00%、91.33%、92.00%、95.33%;Youden指数分别为0.79、0.79、0.86、0.93。结论胱抑素C、β2-微球蛋白及尿微量清蛋白在早期肾损害诊断中均有一定的诊断价值,三种标志物联合检测可以提高诊断的准确度和特异性,值得临床推广。Objective To analyze the value of cystatin C, β2-microglobulin and microalbuminuria in the diagnosis of early renal damage. Methods Hospital urologist admitted 150 patients with early renal damage as the observation group, selected 150 cases of normal aduhs in our hospital as the control group, eystatin C, β2-microglobulin and mi- croalbuminuria were measured in the two groups, and the diagnostic value of three markers alone or in combination detection were compared. Results The cystatin C, β2-microglobulin and microalbuminuria levels in observation group were significantly higher than control group, sensitive rate of cystatin C, β2-microglobulin and microalbuminuria and joint detection degrees were 91.33%,88.00%, 94.00% and 98.00%; Specificity was 88.00%, 91.33%, 92.00%, 95.33%; Youden indexes were 0.79, 0.79, 0.86, 0.93. Conclusion Cystitis C, β2-microglobulin and microalbuminuria have some diagnostic value in the diagnosis of early renal damage, three markers combined detection can improve diagnostic accuracy and specificity, worthy of promotion.

关 键 词：胱抑素C Β2-微球蛋白 尿微量清蛋白 早期肾损害 

分 类 号：R587.1[医药卫生—内分泌]