子痫前期患者外周血T-bet mRNA和GATA3 mRNA的表达水平的探讨  

Explore the peripheral blood of patients with preeclampsia and T-bet mRNA expression levels of GATA3 Myrna

作　　者：王燕云[1] 陈宝丽[1] 宋海澄[2] 左金玲[1] 

机构地区：[1]唐山市妇幼保健院妇产科,河北唐山063000 [2]开滦总医院风湿免疫科,河北唐山063000

出　　处：《临床和实验医学杂志》2014年第15期1249-1251,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨子痫前期患者外周血中的T-bet mRNA与GATA3 mRNA表达情况,分析其在子痫前期发病中的作用及机制。方法选取2011年1月到2012年12月间的46例子痫前期孕妇为研究组,并选取同期46例正常孕妇为对照组,检测两组外周血中的T-bet mRNA与GATA3 mRNA表达情况。结果 T-bet mRNA表达在两组中表达增强,研究组的T-bet mRNA表达量明显高于对照组,差异有统计学意义(P<0.05)。GATA3 mRNA在两组中表达量减弱,研究组GATA3 mRNA表达量明显的低于对照组,差异有统计学意义(P<0.05)。T-bet mRNA/GATA3 mRNA比值在两组中呈现正表达,差异有统计学意义(P<0.05)。结论子痫前期患者外周血中的T-bet mRNA呈现高表达,而GATA3 mRNA呈现低表达,二者在子痫前期发病中具有一定作用。Objective To investigate the peripheral blood of patients with preeclampsia T-bet mRNA and GATA3 mRNA expression and analyze the mechanism in the pathogenesis of preeclampsia. Methods Hospital 46 pregnant women with preeclampsia from January 2011 to December 2012 were selected as the study group. At the same time,46 cases with normal pregnant women were selected as control group. T-bet mRNA and GATA3 mRNA expression in peripheral blood were detected. Results T-bet mRNA expression increased in the two groups. T-bet mRNA expression levels of the study group was significantly higher that of the control group. The difference was statistically significant（ P 〈 0.05）. GATA3 mRNA expression was decreased in the study group and the control group. The study group GATA3 mRNA expression was significantly lower than the control group（ P〈 0. 05）,and with statistically meaningful. T-bet mRNA /GATA3 mRNA expression ratios are presented in two groups. The data between the groups was statistically significant（ P 〈 0. 05）. Conclusion The patients with preeclampsia in T-bet mRNA showed high expression,while GATA3 mRNA showed low expression. Both of which play a role in the pathogenesis of preeclampsia.

关 键 词：子痫前期 T-BET MRNA GATA3 发病机制 

分 类 号：R714.244[医药卫生—妇产科学]