红细胞分布宽度与冠心病慢性心力衰竭相关性的临床研究  

The study of red cell distribution width and chronic heart failur in cardiovascula patients

作　　者：李斌[1,2] 郑刚[2] 王伟[3] 

机构地区：[1]天津医科大学研究生院天津市300070 [2]天津市第三医院心内科 [3]天津市胸科医院心内科

出　　处：《中国心血管病研究》2014年第8期711-714,共4页Chinese Journal of Cardiovascular Research

摘　　要：目的 探讨红细胞分布宽度（RDW）与冠心病合并慢性心力衰竭的相关性.方法 选取冠心病合并慢性心力衰竭患者142例,按红细胞分布宽度标准差（RDWSD）、红细胞分布宽度变异系数（RD-WCV）及左室射血分数（LVEF）分组观察血液指标及超声心动图指标.结果 按照RDWSD进行分组,高RDWSD组的N-末端脑钠肽前体（NT-proBNP）、尿素氮（BUN）、肌酐（CREA）、尿酸（UA）、舒张期左房直径（LAD）、左室舒张末期内径（LVEDD）、纽约心衰分级（NYHA）等指标均明显升高,均高于低RDWSD组（P＜0.05）;按照RDWCV进行分组,高RDWCV组的NT-proBNP、BUN、CREA、UA、LAD、LVEDD、NYHA等指标均明显升高,均高于低RDWCV组（P＜0.05）;按照LVEF进行分组,高LVEF组的NT-proBNP、BUN、CREA、UA、LAD、LVEDD、NYHA等指标均明显升高,均高于低LVEF组（P＜0.05）.结论 患者RDW升高,其NT-proB-NP、BUN、CREA、UA、LAD、LVEDD、NYHA等指标同时升高,NT-proBNP及NYHA心功能分级是国际公认的评价心功能的指标,RDW水平作为一个入院患者的常规检查指标,不仅可以作为心力衰竭患者的预后指标,也可作为丰富心力衰竭临床诊断的一个客观指标.Objective To study the correlation between red cell distribution width and coronary heart dis- ease in patients with chronic heart failure. Methods 142 cases of patients with chronic heart failure complicated with coronary heart disease, according to the RDWSD, RDWCV and LVEF were observed blood indexes and echecardiography index. Results Group by RDWSD, NT-proBNP, BUN, CREA, UA, LAD. LVEDD, NYHA and other indicators of high RDWSD group were significantly elevated, were higher than the low RDWSD group （P〈0.05）. Group by RDWCV, NT-proBNP, BUN, CREA, UA, LAD, LVEDD. NYHA and other indicators of high RDWCV group were significantly elevated, were higher than the low RDWCV group （P〈0.05）. Group by LVEF, NT-proBNP, BUN, CREA. UA, LAD, LVEDD, NYHA and other indicators of high LVEF group were significantly elevated, were higher than the low LVEF group（P〈0.05）. Conclusion Patients with high RDW, in- dicators like NT-proBNP. BUN, CREA, UA, LAD, LVEDD, NYHA, were increasing at the same time, the car-- diac function in NT-proBNP and NYHA grading is the heart function evaluation of the internationally recognized indicators. The level of RDW as a routine examination index of patients, not only can be used as a prognostic fac- tor in patients with heart failure, and can also be used as an objective index of heart failure clinical diagnosis.

关 键 词：红细胞分布宽度 心力衰竭 冠状动脉疾病 

分 类 号：R541.4[医药卫生—心血管疾病]