冠心舒通胶囊对冠状动脉支架置入术后支架内再狭窄的影响  

The influence of Guanxinshutong Capsules on in-stent restenosis after coronary artery stent implantation

作　　者：王前胜[1] 刘东亮[1] 吕云霞[1] 董艳彩[1] 

机构地区：[1]漯河医学高等专科学校附属第一医院(漯河市中心医院)心内科,河南省漯河市462002

出　　处：《中国心血管病研究》2014年第8期757-761,共5页Chinese Journal of Cardiovascular Research

摘　　要：目的 研究冠心舒通胶囊对冠脉支架置入术后支架内再狭窄的影响,初步探讨其作用机制.方法 将冠脉支架置入术成功的102例患者随机分为对照组（51例）及冠心舒痛胶囊组（51例）,检测两组患者术前,术后1d、3d、7d、2周时C反应蛋白（CRP）及白细胞介素-6（IL-6）水平.术后6个月,观察两组患者的心血管事件发生率及心电图ST段、心脏彩超左室射血分数变化情况;复查冠脉造影,观察两组患者支架内再狭窄情况.结果 两组患者术后1d、3d、7d时的CRP及IL-6水平均较术前明显升高（P＜0.05）.术后2周冠心舒通胶囊组的CRP及IL-6水平与术前相比差异无统计学意义（P＞0.05）,但对照组较术前仍偏高（P＜0.05）.冠心舒通胶囊组在术后1d、3d、7d、2周时的CRP及IL-6水平与对照组同时间点相比均明显偏低（P＜0.05）.术后6个月时,冠心舒通胶囊组的各种心血管事件发生率均明显低于对照组（P＜0.05）,心电图有效率、左室射血分数显著高于对照组（P＜0.05）;与对照组相比,支架内再狭窄率明显明显降低（P=0.0285）.结论 冠心舒通胶囊能减少冠脉支架置入术后各种心血管事件的发生率,并且能降低冠脉支架置入术后支架内再狭窄.这种作用可能与冠心舒通胶囊降低支架置入术后炎症反应有关.Objective To study the influence of Guanxinshutong Capsule on in-stent restenosis after coronary artery stent implantation and to explore its mechanism. Methods The 102 patients underwent of success- ful coronary stenting were divided randomly into control group （n=51） and Guanxinshutong Capsule group （n=51）. The C-reactive protein（CRP） and interleukin-6（IL-6） levels of all patients were detected before surgery and after surgery 1 day, 3 days, 7 days, 2 weeks. After 6 months, the incidence of cardiovascular events and ECG ST seg- ment, EF of echocardiography changes of all patients were observed, and in-stent restenosis situation were as- sessed after coronary angiography once again. Restflts CRP and IL-6 levels on after surgery 1 day, 3 days, 7 days of two groups were significantly higher than that of before surgery （P〈O.05）. After surgery 2 weeks, CRP and IL-6 levels of Guanxinshutong Capsule group compared with the before surgery had no statistical significance （P〉 0.05）, but CRP and IL-6 levels of control group was higher than that of before surgery （P〈0.05）. CRP and IL-6 levels on after surgery 1 day, 3 days, 7 days, 2 weeks of Guanxinshutong Capsule group compared with control group at the same time were lower sign/ficanfly （P〈0.05）, After surgery 6 months, all kinds of cardiovascular events incidence in Guanxinshutong Capsule group were lower significantly than that of the control group（P〈0.05 ）, and the effective rate of ECG, left ventricular ejection fraction （EF） of Guanx.inshutong Capsule group were higher significantly than that of the control group （P〈0.05）. After surgery 6 months, the in-stem restenosis rate of Guanxinshutong Capsule group compared with control group was decreased significantly （P=0.0285）. Conclusion Guanxinshutong Capsule can reduce all kinds of cardiovascular events incidence after coronary artery stent implan- tation, and Guanxinshutong Capsule can decrease the in-stent restenosis rate, which seems related to Guanxinshu-

关 键 词：冠心舒通胶囊 冠状动脉 C反应蛋白 白细胞介素-6 支架内再狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]