粉唑醇的化学改性及其衍生物的抑菌活性  

Chemical Modification of Flutriafol and Bacteriostasis of Its Ramifications

作　　者：王丽[1] 何深远 程康华[1] 王蓓[1] 张丽丽[1] 马耀进[1] 

机构地区：[1]南京林业大学,南京210037

出　　处：《东北林业大学学报》2014年第8期152-156,共5页Journal of Northeast Forestry University

基　　金：林业公益性行业科研专项(201104032)

摘　　要：为了提高粉唑醇的杀菌广谱性以及对木材腐朽菌和绿色木霉等霉菌的杀菌活性，对其进行化学改性，经傅克反应、羰基环氧化反应、开环反应得到5种化合物，所有化合物均经质谱（ MS）和核磁共振氢谱（1H NMR）确证。抑菌实验表明，质量分数在0．5％～2％范围内，相同质量分数时，α-（2，4-二氯苯基）-α-（4-氯苯基）-1-氢-1，2，4-三唑-乙醇（3b）和α-（2，4-二氯苯基）-α-（4-甲苯基）-1-氢-1，2，4-三唑-乙醇（3d）对绿色木霉的抑菌效果均优于粉唑醇，3b对彩绒革盖菌、密粘褶菌的抑菌效果与粉唑醇相当。In order to improve the bactericidal broad-spectrum and antibacterial effects on wood decay fungi and mold , flutriafol was chemically modified by Friedel-Crafts acylation, Corey-Chaykovsky reaction and 1,2-Epoxide opening reaction .Five compounds were obtained which were confirmed by the means of MS and 1H NMR.Through bacteriostatic experimentation , in the range of 0.5%-2%and of the same mass fraction,α-（2,4-dichlorophenyl）-α-（4-chlorphenyl）-1-H-1, 2, 4-triazol-alcohol （3b） and α-（2,4-dichlorophenyl）-α-（4-tolyl）-1-H-1, 2, 4-triazol-alcohol （3d） had a stronger inhibitory effect on Trichoderma viride than flutriafol.The inhibitory effect of 3b on Coriolus versicolor and Gloeophyllum trabeum was compa-rable to that of flutriafol .

关 键 词：粉唑醇 化学改性 抑菌效果 

分 类 号：S782.33[农业科学—木材科学与技术]